131043-40-8

Basic information

• Product Name: 2-amino-1,9-dihydro-9-(2-fluoro-4-hydroxy-3-(hydroxymethyl)cyclopentyl)-6H-purin-6-one
• Synonyms: 2-amino-1,9-dihydro-9-(2-fluoro-4-hydroxy-3-(hydroxymethyl)cyclopentyl)-6H-purin-6-one
• CAS NO: 131043-40-8
• Molecular Formula: C11H14 F N5 O3
• Molecular Weight: 0
• Mol File: 131043-40-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 665.7°Cat760mmHg
• Flash Point: 356.4°C
• Appearance: /
• Density: 2.01g/cm³
• Vapor Pressure: 1.26E-18mmHg at 25°C
• Refractive Index: 1.853
• CAS DataBase Reference: 2-amino-1,9-dihydro-9-(2-fluoro-4-hydroxy-3-(hydroxymethyl)cyclopentyl)-6H-purin-6-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-1,9-dihydro-9-(2-fluoro-4-hydroxy-3-(hydroxymethyl)cyclopentyl)-6H-purin-6-one(131043-40-8)
• EPA Substance Registry System: 2-amino-1,9-dihydro-9-(2-fluoro-4-hydroxy-3-(hydroxymethyl)cyclopentyl)-6H-purin-6-one(131043-40-8)

Safety Data

• Hazardous Substances Data: 131043-40-8(Hazardous Substances Data)

Usage

Classification

Nucleoside analog reverse transcriptase inhibitor

Medical Use

Treatment of HIV/AIDS

Mechanism of Action

Inhibits the activity of reverse transcriptase enzyme, crucial for HIV virus replication

Administration

Usually administered orally

Forms Available

Tablets, oral solutions

Combination Therapy

Typically used in combination with other antiretroviral medications

Efficacy

Reduces viral load and improves immune system function in HIV patients

Tolerance

Generally well-tolerated

Adverse Reactions

Can cause serious hypersensitivity reactions in some individuals

InChI:InChI=1/C11H14FN5O3/c12-7-4(2-18)6(19)1-5(7)17-3-14-8-9(17)15-11(13)16-10(8)20/h3-7,18-19H,1-2H2,(H3,13,15,16,20)/t4-,5?,6+,7-/m0/s1

Upstream product

• 142217-78-5 (1S,2S,3S,5S)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-benzyloxy-9H-purin-9-yl]-3-benzyloxy-2-[(benzyloxy)methyl]cyclopentanol 
• 131043-37-3 <1R-(1α,2α,3α,5β)>-3-<<2-amino-6-chloro-5-<(4-chlorophenyl)azo>-4-pyrimidinyl>amino>-2-fluoro-5-hydroxycyclopentanemethanol 
• 131043-39-5 <1R-(1α,2α,3α,5β)>-3-<(2-amino-6-chloro-9H-puyrin-9-yl)amino>-2-fluoro-5-hydroxycyclopentanemethanol 
• 131043-35-1 <1R-(1α,2α,3α,5β)>-3-amino-2-fluoro-5-hydroxycyclopentanemethanol hydrochloride 
• 131043-38-4 <1R-(1α,2α,3α,5β)>-3-<(2,5-diamino-6-chloro-4-pyrimidinyl)amino>-2-fluoro-5-hydroxycyclopentanemethanol 
• 131043-36-2 <1R-(1α,2α,3α,5β)>-3-<(2-amino-6-chloro-4-pyrimidinyl)amino>-2-fluoro-5-hydroxycyclopentanemethanol 
• 123238-61-9 <1S-(1α,2α,3α,4β)>-2-fluoro-4-(phenylmethoxy)-3-<(phenylmethoxy)methyl>-1-cyclopentanamine 

Relevant articles and documents

Synthesis and antiviral activity of 2′-deoxy-6′-substituted carbocyclic nucleosides

A series of 2′-deoxy carbocyclic nucleosides characterized by various 6′-substitutions were synthesized and evaluated for their antiviral activities against three viruses, including hepatitis B virus (HBV), hepatitis C virus, and influenza virus. The in vitro antiviral assays indicated that these nucleosides only showed inhibitory activities against HBV, and the substituted groups at the 6′ position significantly affected the activity. Among them, the guanosine analog 2b bearing a 6′-α-hydroxyl methyl group was the most potent compound with an EC50 value of 80?nM. The present study provided useful information for the discovery of antiviral carbocyclic nucleosides.