1310450-28-2Relevant academic research and scientific papers
Interaction with DNA and different effect on the nucleus of cancer cells for copper(ii) complexes of N-benzyl di(pyridylmethyl)amine
Chen, Qiu-Yun,Fu, Hai-Jian,Zhu, Wei-Hua,Qi, Yan,Ma, Zheng-Ping,Zhao, Kai-Di,Gao, Jing
, p. 4414 - 4420 (2011)
Three new copper(ii) complexes of N-benzyl di(pyridylmethyl)amine (phdpa) were synthesized and characterized by spectroscopic methods. The interaction between CT-DNA and the complexes was studied by UV and fluorescence titration methods. It was found that the complex [(phdpa)Cu(H2O)Ac)](Ac), with the non-planar aromatic heterocyclic ring ligand (phdpa), showed good anticancer properties and could cause the fragmentation of the nucleus, although its interaction with CT-DNA was weaker than that of 1,10-phenanthroline (phen) -based copper(ii) complexes. The anticancer activities of copper(ii) complexes with phdpa and phen based ligands are correlated to their binding constants with DNA, but phen-based copper(ii) complexes did not cause the nucleus fragmentation of HeLa cells. [(phdpa)Cu(H2O)Ac)](Ac) can noticeably decrease the oxygen content of a culture solution and of HeLa cells, which make it a new nucleus and oxygen related anticancer copper(ii) complex. Information obtained here would be helpful in the design of new antitumor complexes in oxidative therapy.
