1310488-05-1Relevant articles and documents
Development of an asymmetric hydrogenation route to (S)- N -Boc-2,6-dimethyltyrosine
Praquin, Celine F. B.,De Koning, Pieter D.,Peach, Philip J.,Howard, Roger M.,Spencer, Sarah L.
, p. 1124 - 1129 (2011)
An improved, simpler and potentially more economical route to (S)-N-Boc-2,6-dimethyltyrosine 1, based on a previously published route, is presented. Key modifications were to prepare the dehydroaminoacid hydrogenation substrate 6 in a one-pot process directly from serine methyl ester and 4-iodo-3,5-dimethylphenyl acetate 4 and to identify a significantly more active asymmetric hydrogenation catalyst that allowed a 5-fold reduction in catalyst loading.
