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1310495-85-2

(E)-4-chloro-3-(2-(4-chlorophenyl)-2-oxoethylidene)indolin-2-one is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1310495-85-2 Structure

  • Basic information

    1. Product Name: (E)-4-chloro-3-(2-(4-chlorophenyl)-2-oxoethylidene)indolin-2-one
    2. Synonyms: (E)-4-chloro-3-(2-(4-chlorophenyl)-2-oxoethylidene)indolin-2-one
    3. CAS NO:1310495-85-2
    4. Molecular Formula:
    5. Molecular Weight: 318.159
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1310495-85-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (E)-4-chloro-3-(2-(4-chlorophenyl)-2-oxoethylidene)indolin-2-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: (E)-4-chloro-3-(2-(4-chlorophenyl)-2-oxoethylidene)indolin-2-one(1310495-85-2)
    11. EPA Substance Registry System: (E)-4-chloro-3-(2-(4-chlorophenyl)-2-oxoethylidene)indolin-2-one(1310495-85-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1310495-85-2(Hazardous Substances Data)

1310495-85-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1310495-85-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,1,0,4,9 and 5 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1310495-85:
(9*1)+(8*3)+(7*1)+(6*0)+(5*4)+(4*9)+(3*5)+(2*8)+(1*5)=132
132 % 10 = 2
So 1310495-85-2 is a valid CAS Registry Number.

1310495-85-2Downstream Products

1310495-85-2Relevant articles and documents

3-ACYLIDENE-2-OXOINDOLE DERIVATIVES FOR INHIBITION OF TRANSGLUTAMINASE 2

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Page/Page column 52, (2012/06/30)

Provided herein are acylidene oxoindole derivatives, compositions including them, and methods of inhibiting transglutaminase 2 and treating diseases mediated by transglutaminase 2 by administering such derivatives and compositions.

Acylideneoxoindoles: A new class of reversible inhibitors of human transglutaminase 2

Kl?ck, Cornelius,Jin, Xi,Choi, Kihang,Khosla, Chaitan,Madrid, Peter B.,Spencer, Andrew,Raimundo, Brian C.,Boardman, Paul,Lanza, Guido,Griffin, John H.

, p. 2692 - 2696 (2011/06/20)

Inhibitors of human transglutaminase 2 (TG2) are anticipated to be useful in the therapy of a variety of diseases including celiac sprue as well as certain CNS disorders and cancers. A class of 3-acylidene-2-oxoindoles was identified as potent reversible inhibitors of human TG2. Structure-activity relationship analysis of a lead compound led to the generation of several potent, competitive inhibitors. Analogs with significant non-competitive character were also identified, suggesting that the compounds bind at one or more allosteric regulatory sites on this multidomain enzyme. The most active compounds had Ki values below 1.0 μM in two different kinetic assays for human TG2, and may therefore be suitable for investigations into the role of TG2 in physiology and disease in animals.

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