131052-46-5

Basic information

• Product Name: C-THIAZOL-4-YL-METHYLAMINE HYDROCHLORIDE
• Synonyms: C-THIAZOL-4-YL-METHYLAMINE HYDROCHLORIDE;C-THIAZOL-5-YL-METHYLAMINE HYDROCHLORIDE;THIAZOL-4-YLMETHYLAMINE HCL;THIAZOL-5-YLMETHYLAMINE HCL;THIAZOL-5-YL-METHYLAMINE HYDROCHLORIDE;Thiazol-4-yl-methylaminehydrochloride;5-Thiazolemethanamine, hydrochloride (1:1);Thiazole-5-methylamine HCl
• CAS NO: 131052-46-5
• Molecular Formula: C4H7ClN2S
• Molecular Weight: 150.63
• EINECS: 604-604-1
• Mol File: 131052-46-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 255.1 °C at 760 mmHg
• Flash Point: 108.1 °C
• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: C-THIAZOL-4-YL-METHYLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: C-THIAZOL-4-YL-METHYLAMINE HYDROCHLORIDE(131052-46-5)
• EPA Substance Registry System: C-THIAZOL-4-YL-METHYLAMINE HYDROCHLORIDE(131052-46-5)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• Hazardous Substances Data: 131052-46-5(Hazardous Substances Data)

Usage

General Description

C-Thiazol-4-yl-methylamine hydrochloride is a chemical compound that contains a thiazole ring and a methylamine group, and is in the form of a hydrochloride salt. It is primarily used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. This chemical may also have other industrial applications as a reagent or building block in chemical reactions. It is important to handle and store C-Thiazol-4-yl-methylamine hydrochloride in accordance with proper safety procedures, as it may pose health and environmental risks if not managed appropriately.

Relevant articles and documents

Catalytic Staudinger Reduction at Room Temperature

We report an efficient catalytic Staudinger reduction at room temperature that enables the preparation of a structurally diverse set of amines from azides in excellent yields. The reaction is based on the use of catalytic amounts of triphenylphosphine as a phosphine source and diphenyldisiloxane as a reducing agent. Our catalytic Staudinger reduction exhibits a high chemoselectivity, as exemplified by reduction of azides over other common functionalities, including nitriles, alkenes, alkynes, esters, and ketones.

Quinazoline derivatives possessing anti-tumor activity

The invention relates to quinazoline derivatives, or pharmaceutically-acceptable salts thereof, which possess anti-tumor activity; to processes for their manufacture; and to pharmaceutical compositions containing them. The invention provides a quinazoline of the formula: STR1 wherein R1 is hydrogen or amino, or alkyl or alkoxy each of up to 6 carbon atoms; or R1 is substituted alkyl or alkoxy each of up to 3 carbon atoms; R2 is hydrogen, alkyl, alkenyl, alkynyl, hydroxyalkyl, halogenoalkyl or cyanoalkyl each of up to 6 carbon atoms; Ar is phenylene or heterocyclene; L is a group of the formula --CO.NH--, --NH.CO--, --CO.NR3 --, --NR3. CO--, --CH=CH--, --CH2 O--, --OCH2, --CH2 S--, --SCH2 --, --CO.CH2 --, --CH2.CO-- or --CO.O--, wherein R3 is alkyl of up to 6 carbon atoms; and Y is aryl or heteroaryl or a hydrogenated derivative thereof: or Y is a group of the formula --A--Y1 in which A is alkylene, cycloalkylene, alkenylene or alkynylene each of up to 6 carbon atoms and Y1 is aryl or heteroaryl or a hydrogenated derivative thereof; or a pharmaceutically-acceptable salt thereof.