1310539-57-1

Basic information

• Product Name: C₂₀H₃₁N₄OP
• Synonyms: C₂₀H₃₁N₄OP
• CAS NO: 1310539-57-1
• Molecular Weight: 374.466
• Mol File: 1310539-57-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₃₁N₄OP(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₃₁N₄OP(1310539-57-1)
• EPA Substance Registry System: C₂₀H₃₁N₄OP(1310539-57-1)

Safety Data

• Hazardous Substances Data: 1310539-57-1(Hazardous Substances Data)

Upstream product

• 1186139-42-3 C₁₉H₃₀N₃OP 
• 5804-85-3 diethylaluminium cyanide 

Downstream Products

• 48108-77-6 (S)-α-phenylglycinenitrile 
• 177723-19-2 (S)-2-N-tert-butoxycarbonylamino-2-phenylethanenitrile 

Relevant articles and documents

The GAP chemistry for chiral N-phosphonyl imine-based Strecker reaction

Chiral N-phosphonyl imines were found to be efficient electrophiles for reaction with diethylaluminium cyanide, a non-volatile and inexpensive cyanide source. The reaction produced chiral Strecker adducts, α-aminonitriles, in excellent chemical yields (94-98%) and diastereoselectivities (95:5 to >99%). This synthesis was confirmed to follow the GAP chemistry (group-assistant-purification chemistry) process, which can avoid traditional chromatography and recrystallization purifications, i.e., the pure chiral α-aminonitriles bearing a chiral N-phosphonyl group can be simply obtained by washing the solid crude products with hexane. The chiral N-phosphonyl auxiliary can be easily cleaved under mildly acidic conditions and quantitatively recycled by a one-time extraction with n-butanol.