1310550-07-2

Basic information

• Product Name: C₁₈H₁₆FN₃O₃
• CAS NO: 1310550-07-2
• Molecular Weight: 341.342
• Mol File: 1310550-07-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₈H₁₆FN₃O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₁₆FN₃O₃(1310550-07-2)
• EPA Substance Registry System: C₁₈H₁₆FN₃O₃(1310550-07-2)

Safety Data

• Hazardous Substances Data: 1310550-07-2(Hazardous Substances Data)

Upstream product

• 148401-38-1 4-amino-8-fluoroquinoline 
• 37527-66-5 3,4-dimethoxyphenylisocyanate 

Relevant articles and documents

Diaryl urea analogues of SB-334867 as orexin-1 receptor antagonists

As a part of our program to develop OX1-CB1 bivalent ligands, we required a better understanding of the basic structure-activity relationships (SARs) of orexin antagonists. A series of SB-334867 analogues were synthesized and evaluated in calcium mobilization assays. SAR results suggest that the 2-methylbenzoxazole moiety may be replaced with a disubstituted 4-aminophenyl group without loss of activity and an electron-deficient system is generally preferred at the 1,5-naphthyridine moiety for OX1 antagonist activity. In particular, substitution of larger potential linkers such as n-hexyl provided compound 33 with equivalent activity at the OX1 receptor compared to the lead compound SB-334867. These compounds should be of value in the development of ligands targeting the orexin-1 receptor and its potential heterodimers.