1310558-70-3Relevant academic research and scientific papers
CuI-catalyzed synthesis of functionalized terminal allenes from 1-alkynes
Luo, Hongwen,Ma, Shengming
, p. 3041 - 3048 (2013/06/27)
Relative to our original protocol that uses CuI (0.5 equiv.), paraformaldehyde (2.5 equiv.), and dicyclohexylamine (1.8 equiv.), a facile and efficient protocol for the gram-scale synthesis of functionalized terminal allenes by using CuI (7.5-10 mol-%), p
Solid-phase synthesis of N-(buta-2,3-dien-1-yl)amides by the Crabbé reaction
Leikoski, Tuomo,Wrigstedt, Pauli,Matikainen, Jorma,Sipil?, Jussi,Yli-Kauhaluoma, Jari
, p. 38 - 42 (2013/03/14)
The Crabbé homologation of polymer-supported propargylamine with paraformaldehyde, CuI, and dicyclohexylamine in 1,4-dioxane at 100 C, followed by cleavage with dilute trifluoroacetic acid, furnishes N-(buta-2,3-dien-1-yl) amides as isolable products. The N-acyltriazene linker on Merrifield resin serves simultaneously as a protecting group for the nucleophilic primary amine. The product diversity is achieved by altering the acyl chloride in the acylation of the triazene linker. In addition to being a new route to nitrogen-containing allenes, our solid-phase method enables immobilization of these reactive cumulated dienes for further synthetic operations.
Gold catalysis: 1,3-Oxazines by cyclisation of allene amides
Hashmi, A. Stephen K.,Schuster, Andreas M.,Litters, Sebastian,Rominger, Frank,Pernpointner, Markus
supporting information; experimental part, p. 5661 - 5667 (2011/06/25)
A series of allene amides was prepared and their gold-catalysed cyclisation was investigated. The formation of six-membered rings, 1,3-oxazines, was observed. Dihydropyrroles originating from intramolecular hydroamination of the distal C=C double bonds of
