131064-07-8

Upstream product

• 115118-26-8 2-Oxo-6-phenyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[2,1-e][1,3]oxazine-5-carboxylic acid methyl ester 
• 115118-24-6 (E)-4-((7S,8R)-8-Phenyl-bicyclo[4.2.0]octa-1,3,5-trien-7-yloxycarbonylamino)-but-2-enoic acid methyl ester 
• 104703-81-3 trans-1-acetoxy-2-phenylbenzocyclobutene 
• 115118-23-5 (7R,8S)-8-Phenyl-bicyclo[4.2.0]octa-1,3,5-trien-7-ol 
• 130975-98-3 (1R,2S,3R,4R)-1-Hydroxy-4-phenyl-1,2,3,4-tetrahydro-naphthalene-2,3-dicarboxylic acid 2-((S)-1-carboxy-ethyl) ester 
• 131064-06-7 (1R,2R,3R,4R)-4-Hydroxy-3-hydroxymethyl-1-phenyl-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid 

Relevant academic research and scientific papers

Dearomatizing cyclization of arylsulfonylalkoxymethyl lithiums: A route to the podophyllotoxin skeleton

(Matrix presented) The phenylsulfonyl group promotes the dearomatizing cyclization of tethered organolithiums onto aromatic rings. With an ether tether, the cyclizations create a new tetrahydrofuran ring, and both cyclization and subsequent electrophilic

A Highly Stereoselective Synthesis of Podophyllotoxin and Analogues Based on an Intramolecular Diels-Alder Reaction

A synthesis of podophyllotoxin and several analogues is described.The key step that generates all four chiral centers of podophylotoxin involves an intramolecular Diels-Alder reaction between an appropriately substituted o-quinodimethane and a pendant cro