1310708-11-2Relevant articles and documents
Simple and convenient approach for synthesis of tetrahydroquinoline derivatives and studies on aza-Cope rearrangement
Rao Lingam, V.S. Prasada,Thomas, Abraham,Mukkanti, Khagga,Gopalan, Balasubramanian
experimental part, p. 1809 - 1828 (2011/06/20)
A simple and novel synthesis of 1,2,3,4-tetrahydroquinoline derivatives by polyphosphoric acid-assisted reaction of N-aryl allyl anilines prepared from anilines has been reported. The generality and scope of the approach has been demonstrated by extending it to the synthesis of 1,2,5,6-tetrahydro-4H- pyrrolo[3,2,1-ij]quinoline (lilolidine) and 2,3,6,7-tetrahydro-1H,5H-pyrido[3,2, 1-ij]quinoline (julolidine). Further, Lewis acid- mediated aza-Cope rearrangement of various N-aryl allyl anilines has been demonstrated.