1310732-18-3

Basic information

• Product Name: tert-Butyl 3-(chlorosulphonyl)azetidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-3-(chlorosulphonyl)azetidine
• Synonyms: 3-(Chlorosulphonyl)azetidine, N-BOC protected;tert-Butyl 3-(chlorosulphonyl)azetidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-3-(chlorosulphonyl)azetidine;3-(chlorosulfonyl)azetidine, n-boc protected
• CAS NO: 1310732-18-3
• Molecular Formula: C₈H₁₄ClNO₄S
• Molecular Weight: 255.71906
• Mol File: 1310732-18-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-Butyl 3-(chlorosulphonyl)azetidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-3-(chlorosulphonyl)azetidine(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl 3-(chlorosulphonyl)azetidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-3-(chlorosulphonyl)azetidine(1310732-18-3)
• EPA Substance Registry System: tert-Butyl 3-(chlorosulphonyl)azetidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-3-(chlorosulphonyl)azetidine(1310732-18-3)

Safety Data

• Hazardous Substances Data: 1310732-18-3(Hazardous Substances Data)

Usage

General Description

Tert-Butyl 3-(chlorosulphonyl)azetidine-1-carboxylate and 1-(tert-Butoxycarbonyl)-3-(chlorosulphonyl)azetidine are both organic chemicals that contain a chlorosulphonyl functional group attached to an azetidine ring. Tert-Butyl 3-(chlorosulphonyl)azetidine-1-carboxylate is a tert-butyl ester derivative of azetidine-1-carboxylic acid, while 1-(tert-Butoxycarbonyl)-3-(chlorosulphonyl)azetidine is a chlorosulphonyl-protected azetidine compound. These chemicals are often used in organic synthesis as building blocks for the production of various pharmaceuticals, agrochemicals, and other fine chemicals. The chlorosulphonyl group serves as a versatile synthetic handle for further functionalization, making these compounds valuable intermediates in the development of complex organic molecules.

Upstream product

• 141699-55-0 tert-butyl 3-hydroxyazetidine-1-carboxylate 
• 141699-58-3 3-methanesulfonyloxy-azetidine-1-carboxylic acid tert-butyl ester 
• 254454-54-1 tert-butyl-3-iodoazetidine-1-carboxylate 
• 605655-08-1 tert-butyl 3-{[(4-methylphenyl)sulfonyl]oxy}azetidine-1-carboxylate 

Relevant articles and documents

NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS

The present invention relates to compounds of formula (I) wherein Q is selected from O or S; R1 is a non-aromatic heterocyclic group comprising at least one ring nitrogen atom, wherein R1 is attached to the sulfur atom of the sulfonylurea group by a ring carbon atom, and wherein R1 may optionally be substituted; and R2 is a cyclic group substituted at the α-position, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.

COMPOUNDS CONTAINING A SULFONIC GROUP AS KAT INHIBITORS

The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

Nitrogen-containing, fluoroalkyl sulfonyl chloride method for the preparation of (by machine translation)

The invention discloses a nitrogen-containing, fluoroalkyl sulfonyl chloride method for preparing, by containing nitrogen/perfluoroalkyl alcohol as the raw material, under the alkaline condition and a sulfonyl chloride the reaction produces the corresponding nitrogen-containing/perfluoroalkyl sulfonate ester, then nitrogen-containing/perfluoroalkyl sulfonate ester with a thio acetic acid potassium generating affinity substitution reaction to produce the nitrogen-containing/Fluoalkyl thiophosphoro acetate, then the chlorine treatment to obtain nitrogen-containing/fluoroalkyl sulfonyl chloride. The synthesis of this invention containing nitrogen (fluoro) alkyl sulfonyl chloride, the compound is a drug, pesticide research and development and production of important pharmaceutical intermediate, the compound of preparation of the alkyl sulfonyl chloride synthesis of pharmaceutical intermediates database, to the market to provide alkyl sulfonyl chloride can be synthetic fragment. Raw materials used in the present invention chemical reagent is commercially available, low cost, short synthetic route, high yield, high product purity chemical, provides high-purity products, so as to obtain higher economic benefits. (by machine translation)