131079-37-3Relevant academic research and scientific papers
Visible-Light-Mediated Intermolecular Radical Conjugate Addition for the Construction of Vicinal Quaternary Carbon Centers
Li, Lei,Fang, Lili,Wu, Weiping,Zhu, Jin
supporting information, p. 5401 - 5406 (2020/07/24)
The visible light-driven organophotoredox catalysis is reported for the construction of vicinal quaternary carbon centers. Intermolecular conjugate addition of alkyl radicals, derived from 2,2-disubstituted dihydroquinazolinones, to Michael acceptors under blue light irradiation and rhodamine B catalysis allows the facile assembly of diverse, vicinal secondary/quaternary, tertiary/quaternary, and quaternary/quaternary carbon centers at room temperature. Our method provides a synthetically versatile protocol since both 2,2-disubstituted dihydroquinazolinones and Michael acceptors can be conveniently prepared from readily available ketones.
One-pot synthesis of malononitriles by free radical reactions of ylidenemalononitrile with Et3B and iodoalkane in a water-ether biphase medium
Tu, Zhijay,Lin, Chunchi,Jang, Yaochung,Jang, Yeong-Jiunn,Ko, Shengkai,Fang, Hulin,Liu, Ju-Tsung,Yao, Ching-Fa
, p. 6133 - 6137 (2007/10/03)
The one-pot synthesis of malononitrile derivatives 4, 6, and 7 in moderate to high yields by the reaction of ylidenemalononitriles 3, prepared in situ from carbonyl compounds 1 and malononitrile 2 in the presence of ammonium acetate in aqueous solution at
tert-Butylation of α,β-unsaturated nitriles by tert-butylmercury halides in the presence of iodide ion
Russell, Glen A.,Chen, Ping,Yao,Kim
, p. 5967 - 5972 (2007/10/02)
Iodide ion promotes the free radical addition of t-BuHgI to acrylonitrile to form t-BuCH2CH(CN)HgI. A facile reaction of the adduct 1-cyanoalkyl radical with t-BuHgI2- is indicated. Further promotion is observed in the pre
