1310810-23-1Relevant articles and documents
Operationally simple and highly (E)-styrenyl-selective heck reactions of electronically nonbiased olefins
Werner, Erik W.,Sigman, Matthew S.
, p. 9692 - 9695 (2011)
Simple, mild, and efficient conditions are reported for a Pd 0-catalyzed Heck reaction that delivers high yields and selectivity for (E)-styrenyl products using electronically nonbiased olefin substrates bearing a range of useful functionality. Preliminary mechanistic studies demonstrate that the σ-donating DMA solvent is crucial for high selectivity. Further studies suggest that the catalyst distinguishes between β-hydrogens on the basis of their relative hydridic character, in contrast to previously reported PdII-catalyzed oxidative reaction conditions.
