131084-35-0 Usage
Uses
Used in Pharmaceutical Industry:
5-PROPOXY-3-(1,2,3,6-TETRAHYDRO-4-PYRIDINYL)-1H-PYRROLO[3,2-B]PYRIDINE HYDROCHLORIDE is used as a therapeutic agent for its anticonvulsant activity. The compound's ability to selectively activate the serotonin 5-HT1B receptor makes it a promising candidate for the treatment of various neurological disorders, such as epilepsy, where it can help to reduce the frequency and severity of seizures.
Used in Research and Development:
In the field of research, 5-PROPOXY-3-(1,2,3,6-TETRAHYDRO-4-PYRIDINYL)-1H-PYRROLO[3,2-B]PYRIDINE HYDROCHLORIDE serves as a valuable tool for studying the role of serotonin 5-HT1B receptors in various physiological and pathological processes. By understanding the interactions between 5-PROPOXY-3-(1,2,3,6-TETRAHYDRO-4-PYRIDINYL)-1H-PYRROLO[3,2-B]PYRIDINE HYDROCHLORIDE and the receptor, researchers can gain insights into the development of new drugs and therapies for a range of conditions, including neurological and psychiatric disorders.
Used in Drug Design and Optimization:
The selective agonist activity of 5-PROPOXY-3-(1,2,3,6-TETRAHYDRO-4-PYRIDINYL)-1H-PYRROLO[3,2-B]PYRIDINE HYDROCHLORIDE towards the serotonin 5-HT1B receptor also makes it a valuable starting point for drug design and optimization efforts. Researchers can use 5-PROPOXY-3-(1,2,3,6-TETRAHYDRO-4-PYRIDINYL)-1H-PYRROLO[3,2-B]PYRIDINE HYDROCHLORIDE as a template to develop new molecules with improved potency, selectivity, and pharmacokinetic properties, ultimately leading to more effective treatments for various medical conditions.
Biological Activity
Potent, selective 5-HT 1B agonist (K i values are 89, 2, 860, 49 and 1,600 nM for 5-HT 1A , 5-HT 1B , 5-HT 1C , 5-HT 1D and 5-HT 2 receptors respectively). Centrally active upon systemic administration in vivo .
Biochem/physiol Actions
CP-94,253 is a potent and selective serotonin 5-HT1B receptor agonist with approximately 25x and 40x selectivity over the closely related 5-HT1D and 5-HT1A receptors. Ki values are 89, 2, 860, 49 and 1,600 nM for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D and 5-HT2 receptors respectively. CP-94,253 was found to be anxiolytic in animal models; dose-dependently enhanced reinforcing effects of cocaine (self-administration);and reduced food intake.
Check Digit Verification of cas no
The CAS Registry Mumber 131084-35-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,1,0,8 and 4 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 131084-35:
(8*1)+(7*3)+(6*1)+(5*0)+(4*8)+(3*4)+(2*3)+(1*5)=90
90 % 10 = 0
So 131084-35-0 is a valid CAS Registry Number.
InChI:InChI=1/C15H19N3O.ClH/c1-2-9-19-14-4-3-13-15(18-14)12(10-17-13)11-5-7-16-8-6-11;/h3-5,10,16-17H,2,6-9H2,1H3;1H
