1310877-29-2

Upstream product

• 79110-05-7 1-(2-fluoro-5-nitrophenyl)ethanone 
• 1075230-62-4 (R)-2-methylpropane-2-sulfinic acid [1-(2-fluoro-5-nitrophenyl)-(E)-ethylidene]amide 
• 1310877-28-1 N-(3-((S)-2-(((R)-tert-butylsulfinyl)amino)-4-methylpent-4-en-2-yl)-4-fluorophenyl)-2,2,2-trifluoroacetamide 

Downstream Products

• 1310877-30-5 (S)-N-(3-(2-amino-4-oxopentan-2-yl)-4-fluorophenyl)-2,2,2-trifluoroacetamide 
• 1310877-31-6 C₁₄H₁₂F₄N₂O₂S 
• 1310877-32-7 C₃₂H₃₅F₄N₃O₆S 
• 1310877-34-9 (S)-N-(3-(2-(bis(2,4-dimethoxybenzyl)amino)-4,6-dimethyl-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-2,2,2-trifluoroacetamide 
• 1310877-35-0 (S)-4-(5-amino-2-fluorophenyl)-N,N-bis(2,4-dimethoxybenzyl)-4,6-dimethyl-4H-1,3-oxazin-2-amine 
• 1310877-36-1 (S)-N-(3-(2-(bis(2,4-dimethoxybenzyl)amino)-4,6-dimethyl-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide 
• 1310877-10-1 (S)-N-(3-(2-amino-4,6-dimethyl-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide 
• 1374001-11-2 C₂₀H₁₆FN₇O 
• 1374001-36-1 C₁₃H₁₄FN₅ 
• 1374001-35-0 C₁₅H₁₃F₄N₅O 
• 1374001-34-9 C₁₄H₁₄F₄N₄O 
• 1374001-33-8 C₁₉H₂₂F₄N₄O₃ 
• 1374001-31-6 C₁₈H₂₂F₄N₂O₄ 

Relevant academic research and scientific papers

Rational Design of Novel 1,3-Oxazine Based β-Secretase (BACE1) Inhibitors: Incorporation of a Double Bond to Reduce P-gp Efflux Leading to Robust Aβ Reduction in the Brain

Accumulation of Aβ peptides is a hallmark of Alzheimer's disease (AD) and is considered a causal factor in the pathogenesis of AD. β-Secretase (BACE1) is a key enzyme responsible for producing Aβ peptides, and thus agents that inhibit BACE1 should be bene

FUSED AMINODIHYDROPYRIMIDINE DERIVATIVE

The present invention provides, for example, the following compound: wherein ring A is a substituted or unsubstituted carbocycle or a substituted or unsubstituted heterocycle, X1—X2═X3 is CR5—CR6═CRs

OXAZINE DERIVATIVES

The present invention provides, for example, a compound mentioned below as a medicament for treating or preventing the diseases induced by production, secretion or deposition of amyloid-β proteins. A compound of the formula (I): wherein R1, Rs