1310877-95-2Relevant academic research and scientific papers
HISTONE DEMETHYLASE INHIBITORS AND METHODS FOR USING THE SAME
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, (2013/06/05)
The present invention provides compounds, or derivatives or prodrugs thereof, that comprise a methyllysine mimic, and an α-ketoglutarate mimic that are attached through a linker and methods for using and producing the same. In some embodiments, compounds
A selective inhibitor and probe of the cellular functions of jumonji C domain-containing histone demethylases
Luo, Xuelai,Liu, Yongxiang,Kubicek, Stefan,Myllyharju, Johanna,Tumber, Anthony,Ng, Stanley,Che, Ka Hing,Podoll, Jessica,Heightman, Tom D.,Oppermann, Udo,Schreiber, Stuart L.,Wang, Xiang
, p. 9451 - 9456 (2011/08/04)
Histone methylations are important chromatin marks that regulate gene expression, genomic stability, DNA repair, and genomic imprinting. Histone demethylases are the most recent family of histone-modifying enzymes discovered. Here, we report the character
