131111-05-2Relevant academic research and scientific papers
A facile synthesis of C(3)-alkenyl substituted cephems through addition-cyclization of allenecarboxylates derived from penicillin
Tanaka, Hideo,Kameyama, Yutaka,Sumida, Shin-Ichi,Torii, Sigeru
, p. 7029 - 7030 (1992)
A short-cut route to cephalosporins bearing alkenyl substituents on the C(3)-position through copper(I) chloride-promoted Michael-type addition of alkenyltributyltins to allenecarboxylates, derived from penicillin, is described.
Synthesis of 3-alkenyl-Δ3-cephems via sequential reductive 1,2- elimination/ addition/cyclization in an alkenyltin/copper(I) chloride/bpy system
Tanaka, Hideo,Tokumaru, Yoshihisa,Torii, Sigeru
, p. 774 - 776 (2007/10/03)
A sequential reductive 1,2-elimination-addition-cyclization of 3,4- disubstituted butenoates derived from penicillin is performed successfully by treatment with alkenyltin, copper(I) chloride and 2,2'-bipyridine (bpy) in N- methyl-2-pyrrolidinone (NMP) to afford 3-alkenyl-Δ3-cephems.
Palladium in Cephalosporin Chemistry: Mild Triflate Couplings in the Absence of Phosphines and Halide Donors
Baker, Stephen R.,Roth, Gregory P.,Sapino, Chester
, p. 2185 - 2189 (2007/10/02)
Palladium catalyzed triflate-organostannane couplings are shown to proceed in a very mild manner in the absence of added phosphine and halide reagents.This protocol has been demonstrated for 3-trifloxycephems and vinyltriflates.
