1311136-84-1 Usage
Uses
Used in Neuroscience Research:
(5R)-5-ethyl-3-(6-[4-methyl-3-(methyloxy)phenyl]oxy-3-pyridinyl)-2,4-imidazolidinedione is used as a research tool for studying the role of Kv3 potassium channels in regulating neuronal excitability. Its ability to modulate the firing of parvalbumin-positive cortical interneurons makes it a valuable compound for understanding the underlying mechanisms of various neurological disorders and developing potential therapeutic strategies.
Used in Drug Development:
(5R)-5-ethyl-3-(6-[4-methyl-3-(methyloxy)phenyl]oxy-3-pyridinyl)-2,4-imidazolidinedione is used as a lead compound in the development of new drugs targeting Kv3 potassium channels. Its selectivity for Kv3.1b, Kv3.2a, and Kv3.3 channels over other ion channels and receptors makes it a promising candidate for the treatment of neurological disorders associated with abnormal neuronal excitability.
Used in Ion Channel Modulation:
(5R)-5-ethyl-3-(6-[4-methyl-3-(methyloxy)phenyl]oxy-3-pyridinyl)-2,4-imidazolidinedione is used as a modulator of ion channels, specifically the Kv3 potassium channels. Its ability to selectively modulate these channels can be utilized in the development of drugs targeting various ion channelopathies and related conditions.
Used in Serotonin and Nicotinic Acetylcholine Receptor Inhibition:
(5R)-5-ethyl-3-(6-[4-methyl-3-(methyloxy)phenyl]oxy-3-pyridinyl)-2,4-imidazolidinedione is used as an inhibitor of the serotonin (5-HT) transporter, 5-HT3 receptor, and α1 subunit-containing nicotinic acetylcholine receptor (nAChR). This makes it a potential candidate for the development of drugs targeting these receptors and transporters, which are involved in various psychiatric and neurological disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 1311136-84-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,1,1,1,3 and 6 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1311136-84:
(9*1)+(8*3)+(7*1)+(6*1)+(5*1)+(4*3)+(3*6)+(2*8)+(1*4)=101
101 % 10 = 1
So 1311136-84-1 is a valid CAS Registry Number.
1311136-84-1Relevant academic research and scientific papers
HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS
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, (2013/10/22)
The invention provides compounds of formula (I): Said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
IMIDAZOLIDINEDIONE DERIVATIVES
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, (2011/06/26)
The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, sleep disorders or epilepsy.
