1311147-63-3Relevant academic research and scientific papers
Nucleobase and ribose modifications control immunostimulation by a MicroRNA-122-mimetic RNA
Peacock, Hayden,Fucini, Raymond V.,Jayalath, Prasanna,Ibarra-Soza, Jose M.,Haringsma, Henry J.,Flanagan, W. Michael,Willingham, Aarron,Beal, Peter A.
, p. 9200 - 9203 (2011/08/04)
Immune stimulation is a significant hurdle in the development of effective and safe RNA interference therapeutics. Here, we address this problem in the context of a mimic of microRNA-122 by employing novel nucleobase and known 2′-ribose modifications. The
