1311151-30-0

Basic information

• Product Name: C₂₈H₂₅F₆N₃O₆S
• CAS NO: 1311151-30-0
• Molecular Weight: 645.579
• Mol File: 1311151-30-0.mol

Chemical Properties

• CAS DataBase Reference: C₂₈H₂₅F₆N₃O₆S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₈H₂₅F₆N₃O₆S(1311151-30-0)
• EPA Substance Registry System: C₂₈H₂₅F₆N₃O₆S(1311151-30-0)

Safety Data

• Hazardous Substances Data: 1311151-30-0(Hazardous Substances Data)

Upstream product

• 1279816-75-9 C₂₀H₂₈N₂O₆ 
• 149057-19-2 4-((benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid 
• 1311150-46-5 C₂₆H₃₀F₃N₃O₆ 
• 1311150-69-2 C₂₁H₂₂F₃N₃O₄ 
• 777-44-6 3-(Trifluoromethyl)benzenesulfonyl chloride 

Downstream Products

• 1311151-88-8 C₂₀H₁₉F₆N₃O₄S 
• 1311150-01-2 C₂₆H₂₅F₆N₅O₆S 

Relevant articles and documents

SAR studies on a series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl) piperazine-2-carboxamides: Potent inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus

Described herein is the initial optimization of (+/-) N-benzyl-4- heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamide (1), a hit discovered in a high throughput screen run against the NS5B polymerase enzyme of the hepatitis C virus. This effort resulted in the identification of (S)-N-sec-butyl-6-((R)-3- (4-(trifluoromethoxy)benzylcarbamoyl)-4-(4-(trifluoromethoxy)phenylsulfonyl) piperazin-1-yl)pyridazine-3-carboxamide (2), that displayed potent replicon activities against HCV genotypes 1b and 1a (EC50 1b/1a = 7/89 nM).