1311157-62-6

Basic information

• Product Name: 4-[4-(1-butyl-1H-1,2,3-triazole-4-yl)butoxy]-3-methoxybenzaldehyde
• Synonyms: 4-[4-(1-butyl-1H-1,2,3-triazole-4-yl)butoxy]-3-methoxybenzaldehyde
• CAS NO: 1311157-62-6
• Molecular Weight: 331.415
• Mol File: 1311157-62-6.mol

Chemical Properties

• CAS DataBase Reference: 4-[4-(1-butyl-1H-1,2,3-triazole-4-yl)butoxy]-3-methoxybenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[4-(1-butyl-1H-1,2,3-triazole-4-yl)butoxy]-3-methoxybenzaldehyde(1311157-62-6)
• EPA Substance Registry System: 4-[4-(1-butyl-1H-1,2,3-triazole-4-yl)butoxy]-3-methoxybenzaldehyde(1311157-62-6)

Safety Data

• Hazardous Substances Data: 1311157-62-6(Hazardous Substances Data)

Upstream product

• 121-33-5 vanillin 
• 10297-06-0 1-chloro-5-hexyne 
• 1001289-56-0 3-methoxy-4-(hex-5-yn-1-yloxy)benzaldehyde 
• 7332-00-5 n-butylazide 

Downstream Products

• 1311157-65-9 1-({4-[4-(1-butyl-1H-1,2,3-triazole-4-yl)butoxy]-3-methoxyphenyl}methyl)-4-(2-methoxyphenyl)piperazine 

Relevant articles and documents

Bivalent dopamine D2 receptor ligands: Synthesis and binding properties

Dopamine D2 receptor homodimers might be of particular importance in the pathophysiology of schizophrenia and, thus, serve as promising target proteins for the discovery of atypical antipsychotics. A highly attractive approach to investigate and control GPCR dimerization may be provided by the exploration and characterization of bivalent ligands, which can act as molecular probes simultaneously binding two adjacent binding sites of a dimer. The synthesis of bivalent dopamine D2 receptor ligands of type 1 is presented, incorporating the privileged structure of 1,4-disubstituted aromatic piperidines/piperazines (1,4-DAPs) and triazolyl-linked spacer elements. Radioligand binding studies provided diagnostic insights when Hill slopes close to two for bivalent ligands with particular spacer lengths and a comparative analysis with respective monovalent control ligands and unsymmetrically substituted analogues indicated a bivalent binding mode with a simultaneous occupancy of two neighboring binding sites.