131118-90-6

Basic information

• Product Name: (+/-)-benzyl (oxiran-2-ylmethyl)carbamate
• Synonyms: (+/-)-benzyl (oxiran-2-ylmethyl)carbamate
• CAS NO: 131118-90-6
• Molecular Weight: 207.229
• Mol File: 131118-90-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (+/-)-benzyl (oxiran-2-ylmethyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-benzyl (oxiran-2-ylmethyl)carbamate(131118-90-6)
• EPA Substance Registry System: (+/-)-benzyl (oxiran-2-ylmethyl)carbamate(131118-90-6)

Safety Data

• Hazardous Substances Data: 131118-90-6(Hazardous Substances Data)

Upstream product

• 5041-33-8 N-(Benzyloxycarbonyl)allylamine 
• 175027-92-6 1-bromo-3-(N-benzyloxycarbonyl)amino-2-propanone 
• 501-53-1 benzyl chloroformate 
• 31139-36-3 dibenzyl dicarbonate 

Downstream Products

• 727412-96-6 N-(2,6-dimethylphenyl)-2-(4-{2-hydroxy-3-[(phenylmethoxy)carbonylamino]propyl}piperazinyl)acetamide 
• 1072827-24-7 (RS)-{2-hydroxy-3-[4-(6-methoxy-[1,5]naphthyridin-4-yl)-piperazin-1-yl]-propyl}-carbamic acid benzyl ester 
• 641616-99-1 (R)-2-[(N-benzyloxycarbonyl)aminomethyl]oxirane 
• 1334144-98-7 (S)-benzyl (3-fluoro-2-hydroxypropyl)carbamate 
• 42746-49-6 5-Benzyl-1,3-oxazolidin-2-one 
• 230300-09-1 {3-[isobutyl-(4-methoxy-benzenesulfonyl)-amino]-2-oxo-1-phenylsulfanyl-propyl}-carbamic acid benzyl ester 
• 230300-05-7 {3-[isobutyl-(4-methoxy-benzenesulfonyl)-amino]-2-oxo-propyl}-carbamic acid benzyl ester 

Relevant articles and documents

CONTRAST AGENTS

The present invention relates to new class of functionalized polyazamacrocycles including at least one phosphonic or phosphinic group linked to a nitrogen atom of the macrocyclic cage, and capable of chelating paramagnetic metal ions, their chelated compl

Mechanistic investigations of cooperative catalysis in the enantioselective fluorination of epoxides

This report describes mechanistic studies of the (salen)Co- and amine-cocatalyzed enantioselective ring opening of epoxides by fluoride. The kinetics of the reaction, as determined by in situ 19F NMR analysis, are characterized by apparent first-order dependence on (salen)Co. Substituent effects, nonlinear effects, and reactivity with a linked (salen)Co catalyst provide evidence for a rate-limiting, bimetallic ring-opening step. To account for these divergent data, we propose a mechanism wherein the active nucleophilic fluorine species is a cobalt fluoride that forms a resting-state dimer. Axial ligation of the amine cocatalyst to (salen)Co facilitates dimer dissociation and is the origin of the observed cooperativity. On the basis of these studies, we show that significant improvements in the rates, turnover numbers, and substrate scope of the fluoride ring-opening reactions can be realized through the use of a linked salen framework. Application of this catalyst system to a rapid (5 min) fluorination to generate the unlabeled analog of a known PET tracer, F-MISO, is reported.

SUBSTITUTED HETEROCYCLIC COMPOUNDS

Disclosed are novel piperazine derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unsta