131122-73-1

Upstream product

• 122-78-1 phenylacetaldehyde 
• 131122-67-3 2-((S)-2-Methoxymethyl-pyrrolidine-1-carbonyl)-benzaldehyde 
• 85-44-9 phthalic anhydride 
• 131122-69-5 [2-(1,2-Dihydroxy-3-phenyl-propyl)-phenyl]-((S)-2-methoxymethyl-pyrrolidin-1-yl)-methanone 
• 136935-20-1 (2-Hydroxymethyl-phenyl)-((S)-2-methoxymethyl-pyrrolidin-1-yl)-methanone 
• 136935-19-8 2-((S)-2-Methoxymethyl-pyrrolidine-1-carbonyl)-benzoic acid methyl ester 
• 137720-43-5 (S)-N-(2-carbomethoxybenzoyl)-2-(1-methoxy-1-methylethyl)pyrrolidine 
• 137720-44-6 (S)-N-<2-(hydroxymethyl)benzoyl>-2-(1-methoxy-1-methylethyl)pyrrolidine 

Relevant academic research and scientific papers

A SINGLE STEP ENANTIOSELECTIVE PROCESS FOR THE PREPARATION OF 3-SUBSTITUTED CHIRAL PHTHALIDES

The present invention discloses single step, highly enantioselective catalytic oxidative cyclization process for the synthesis of 3-substituted chiral phthalides. In particular, the invention discloses asymmetric synthesis of chiral phthalides via synergetic nitrile accelerated oxidative cyclization of o-cyano substituted aryl alkenes in high yield and enantiomeric excess (ee) in short reaction time. Also, disclosed herein is "one -pot" asymmetric synthesis of biologically important natural compounds having 3-substituted chiral phthalide structural framework in the molecule.

DIASTEREO- AND ENANTIOSELECTIVE SYNTHESIS OF 1,2-DIOLS BY VANADIUM(II) PROMOTED PINACOL CROSS COUPLING

The V(II) promoted pinacol cross coupling of a chiral aromatic aldehyde with achiral aliphatic aldehydes occurs to afford syn diols in up to 91:9 diastereoisomeric ratio and up to 84percent enantiomeric excess.The pinacol coupling of (S)-lactaldehyde and (R)-glyceraldehyde derivatives has also been studied and matching and mis-matching pairs have been identified.The stereochemistry of the products was established by correlation.The sense and degree of stereoselection is discussed.

Vanadium (II) promoted diastereo- and enantioselective intermolecular pinacol cross coupling

The cross coupling reaction promoted by [V2Cl3(THF)6]2[Zn2Cl6] of some aliphatic aldehydes with an aromatic aldehyde bearing a chiral auxiliary occurs in a stereocontrolled fashion to give