131122-74-2

Upstream product

• 131122-70-8 [2-(2-Cyclohexyl-1,2-dihydroxy-ethyl)-phenyl]-((S)-2-methoxymethyl-pyrrolidin-1-yl)-methanone 
• 2043-61-0 cyclohexanecarbaldehyde 
• 131122-67-3 2-((S)-2-Methoxymethyl-pyrrolidine-1-carbonyl)-benzaldehyde 
• 136935-19-8 2-((S)-2-Methoxymethyl-pyrrolidine-1-carbonyl)-benzoic acid methyl ester 
• 137720-45-7 (S)-N-(2-carbomethoxybenzoyl)-2-(diphenylhydroxymethyl)pyrrolidine 
• 85-44-9 phthalic anhydride 
• 137720-49-1 (S)-2-(diphenylhydroxymethyl)-1-(2-formylbenzoyl)pyrrolidine 

Relevant academic research and scientific papers

DIASTEREO- AND ENANTIOSELECTIVE SYNTHESIS OF 1,2-DIOLS BY VANADIUM(II) PROMOTED PINACOL CROSS COUPLING

The V(II) promoted pinacol cross coupling of a chiral aromatic aldehyde with achiral aliphatic aldehydes occurs to afford syn diols in up to 91:9 diastereoisomeric ratio and up to 84percent enantiomeric excess.The pinacol coupling of (S)-lactaldehyde and (R)-glyceraldehyde derivatives has also been studied and matching and mis-matching pairs have been identified.The stereochemistry of the products was established by correlation.The sense and degree of stereoselection is discussed.

Vanadium (II) promoted diastereo- and enantioselective intermolecular pinacol cross coupling

The cross coupling reaction promoted by [V2Cl3(THF)6]2[Zn2Cl6] of some aliphatic aldehydes with an aromatic aldehyde bearing a chiral auxiliary occurs in a stereocontrolled fashion to give