131124-60-2

Basic information

• Product Name: 2,4,5-didehydro-L-Leu⁵>Leu-enkephalin
• Synonyms: 2,4,5-didehydro-L-Leu⁵>Leu-enkephalin
• CAS NO: 131124-60-2
• Molecular Weight: 567.642
• Mol File: 131124-60-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,4,5-didehydro-L-Leu⁵>Leu-enkephalin(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,5-didehydro-L-Leu⁵>Leu-enkephalin(131124-60-2)
• EPA Substance Registry System: 2,4,5-didehydro-L-Leu⁵>Leu-enkephalin(131124-60-2)

Safety Data

• Hazardous Substances Data: 131124-60-2(Hazardous Substances Data)

Upstream product

• 131177-58-7 Fmoc-4,5-didehydro-DL-leucine 
• 86060-85-7 Fmoc-Gly-OPfp 
• 86060-93-7 Fmoc-Tyr(tBu)-OPfp 
• 127633-32-3 Fmoc-4,5-didehydro-D,L-leucine Benzotriazole Ester 
• 131124-64-6 Fmoc-D-Ala Benzotriazole Ester 

Downstream Products

• 60284-47-1 D-Ala₂-Leu₅-enkephalin 

Relevant articles and documents

Synthesis of 2>Leu-enkephalin and 2,D-Leu5>Leu-enkephalin with High Specific Tritiated Activity in the Leucine Residue

2>Leu-enkephalin and 2,D-Leu5>Leu-enkephalin (DADLE) labelled with tritium in the leucine residue have been prepared.Synthesis of the precursor peptides, 2,4,5-didehydro-L-Leu5>Leu-enkephalin and 2,4,5-didehydro-D-Leu5>Leu-enkephalin, was carried out by solid-phase synthesis using Fmoc amino acid derivatives, followed by diastereoisomeric separation on HPLC.These peptides were tritiated catalytically to yield DALE with a specific activity of 5.35 TBq mmol-1 and DADLE with that of 5.43 TBq mmol-1, respectively.The distribution of tritium label was investigated by HPLC with a radioisotopic detector following acidic hydrolysis, which confirmed that the tritium label in both labelled peptides was exclusively located at the leucine residue.