1311265-05-0

Upstream product

• 51483-92-2 6-bromo-1-benzopyran-4(4H)-one 
• 1589-82-8 phenylmagnesium bromide 
• 1450-75-5 5-Bromo-2-hydroxyacetophenone 
• 122-78-1 phenylacetaldehyde 

Downstream Products

• 1311265-06-1 2-benzyl-6-bromospiro[chroman-4,4'-imidazolidine]-2',5'-dione 

Relevant academic research and scientific papers

PYRIDIN-3-YL ACETIC ACID DERIVATIVES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION

Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV or AIDS. (I)

S PIRO [CHROMAN - 4, 4 ' - IMIDAZOL] ONES AS BETA - SECRETASE INHIBITORS

The invention provides novel spirochroman compounds of Formulas I and II that inhibit β-secretase cleavage of APP and are useful as therapeutic agents for treating neurodegenerative diseases.