1311298-06-2Relevant academic research and scientific papers
Total synthesis of the antiinflammatory and proresolving protectin D1
Ogawa, Narihito,Kobayashi, Yuichi
, p. 3001 - 3004 (2011)
Stereoselective total synthesis of protectin D1 was completed through construction of the Z,E,E-triene structure by using the Suzuki coupling between the vinyl borane (C13-C22) and the vinyl iodide (C1-C12). The Z-enyne, the acetylene precursor of the vinyl borane was synthesized from optically active γ-TMS allylic alcohol in a straightforward way. On the other hand, the vinyl iodide was prepared by using Wittig reaction between the C8-C12 aldehyde possessing the requisite iodo-olefin moiety and the C1-C7 phosphonium iodide.
