1311298-75-5

Upstream product

• 1311298-57-3 3-(4,4'-dimethoxytrityloxymethyl)benzylamine 
• 1311298-55-1 3-(4,4'-dimethoxytrityloxymethyl)benzonitrile 
• 1311298-73-3 3-(4,4'-dimethoxytrityloxymethyl)benzylisothiocyanate 
• 1311298-52-8 2-azidomethyl-6-tertbutyldimethylsilyloxymethylpyridine 
• 150058-64-3 (6-(((tert-butyldimethylsilyl)oxy)methyl)pyridin-2-yl)methanol 
• 1195-59-1 2.6-bis(hydroxymethyl)pyridine 
• 5453-67-8 2,6-bis(methoxycarbonyl)pyridine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 874-97-5 3-(hydroxymethyl)benzonitrile 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 1311298-77-7 N-[3-(4,4'-dimethoxytrityloxymethyl)benzyl]-N'-[(6-hydroxymethylpyridine-2-yl)methyl]thiourea 
• 1311298-79-9 C₄₁H₄₁N₃O₇S 

Relevant academic research and scientific papers

Chemically modified siRNAs and miRNAs bearing urea/thiourea-bridged aromatic compounds at their 3′-end for RNAi therapy

We have developed chemically modified siRNAs and miRNAs bearing urea/thiourea-bridged aromatic compounds at their 3′-end for RNAi therapy. Chemically modified RNAs possessing urea/thiourea-bridged aromatic compounds instead of naturally occurring dinucleo

AROMATIC COMPOUND, MODIFICATION CARRIER THAT USES SAME AND IS USED FOR SYNTHESIZING AN OLIGONUCLEOTIDE DERIVATIVE, OLIGONUCLEOTIDE DERIVATIVE, AND OLIGONUCLEOTIDE CONSTRUCT

The present invention provides an oligonucleotide derivative that enables to easily synthesize an oligonucleotide derivative chemically modified at the 3'-end with two moieties each having a benzene or pyridine structure with a few steps, an aromatic compound serving as a precursor for preparing the modification carrier for synthesizing oligonucleotide derivative, and the oligonucleotide derivative and the oligonucleotide construct using the same, that is chemically modified at the 3'-end with two moieties each having a benzene or pyridine structure, and has good permeability through a cell membrane and excellent nuclease resistance. The modification carrier for synthesizing oligonucleotide derivative, comprising a unit and a carrier carrying the unit directly or via a linker, wherein the unit is represented by the formula (a): wherein, R1 to R6 each independently represent hydrogen or a substituent other than hydrogen; Z1 and Z2 each independently represent CH or nitrogen; and X represents oxygen or sulfur.