1311369-72-8

Basic information

• Product Name: 1-(tetrahydro-3-furanyl)-1H-pyrazol-4-amine
• Synonyms: 1-(tetrahydro-3-furanyl)-1H-pyrazol-4-amine;(S)-1-(tetrahydrofuran-3-yl)-1H-pyrazol-4-amine;1-(oxolan-3-yl)-1H-pyrazol-4-amine;1-(oxolan-3-yl)pyrazol-4-amine
• CAS NO: 1311369-72-8
• Molecular Formula: C7H11N3O
• Molecular Weight: 153.18174
• Mol File: 1311369-72-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 345.5±32.0 °C(Predicted)
• Appearance: /
• Density: 1.43±0.1 g/cm3(Predicted)
• PKA: 4.05±0.19(Predicted)
• CAS DataBase Reference: 1-(tetrahydro-3-furanyl)-1H-pyrazol-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(tetrahydro-3-furanyl)-1H-pyrazol-4-amine(1311369-72-8)
• EPA Substance Registry System: 1-(tetrahydro-3-furanyl)-1H-pyrazol-4-amine(1311369-72-8)

Safety Data

• Hazardous Substances Data: 1311369-72-8(Hazardous Substances Data)

Usage

Uses

1-(Oxolan-3-yl)pyrazol-4-aminea useful biulding block for synthesizing selective imidazopyridine and imidazopyridazine mTOR inhibitors.

Upstream product

• 1428776-15-1 4-nitro-1-(tetrahydrofuran-3-yl)-1H-pyrazole 

Relevant articles and documents

ATF6 MODULATORS AND USES THEREOF

Compounds (1-2) as modulators of Activating Transcription Factor 6 (ATF6) are provided. The compounds may find use as therapeutic agents for the treatment of diseases or disorders mediated by ATF6 and may find particular use in the treatment of viral infections, neurodegenerative diseases, vascular diseases, or cancer. (Formula (1-2))

2-substituted parazoleamino-4-substituted amino-5-pyrimidine formamide compound, composition and application thereof

The invention relates to a series of new compounds as a JAK inhibitor, as well as compositions and applications thereof, and particularly provides a series of compounds (I) that have a strong JAK inhibiting activity, or stereisomers, geometrical isomers, tautomers, pharmaceutically acceptable salts, prodrugs, metabolites, isotope derivatives, and solvates, as well as medicine compositions comprising such compounds. The invention also discloses applications of the compounds or the medicine compositions in preparation of a medicine, which is used for treatment of autoimmune diseases or cancer.

PYRROLOPYRIMIDINE AND PURINE DERIVATIVES

The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Q, T, V, W, X, Y, Z, ring A, R1, R2, R3, R4, R5, R5a, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17 and m are defined herein. There novel pyrrolopyrimidine and purine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.