1311377-57-7Relevant articles and documents
Diversity-oriented synthesis of 1,3-benzodiazepines
Wang, Gaigai,Liu, Chao,Li, Binbin,Wang, Yingchun,Van Hecke, Kristof,Van der Eycken, Erik V.,Pereshivko, Olga P.,Peshkov, Vsevolod A.
, p. 6372 - 6380 (2017)
A concise assembly of the 1,3-benzodiazepine core from A3-coupling-derived propargylamines and ortho-bromophenylisocyanates is described. The developed synthetic sequence involves the addition of propargylamine to isocyanate followed by palladium-catalyzed intramolecular alkyne hydroarylation that could be accomplished in a stepwise or one-pot manner.
Copper-Catalyzed Reaction of Secondary Propargylamines with Ethyl Buta-2,3-dienoate for the Synthesis of 1,6-Dihydropyridines
Liu, Chao,Wang, Gaigai,Wang, Yuqing,Pereshivko, Olga P.,Peshkov, Vsevolod A.
supporting information, p. 1981 - 1985 (2018/12/05)
A copper(I) bromide-catalyzed reaction of A3-coupling-derived propargylamines with ethyl buta-2,3-dienoate for the fast assembly of a 1,6-dihydropyridine core is described. The developed protocol was tested on a variety of secondary propargylamines and the possibility of a one-pot synthesis of 1,6-dihydropyridine through the A3-coupling and subsequent ethyl buta-2,3-dienoate incorporation was investigated.
Tetrasubstituted 2-imidazolones via ag(I)-catalyzed cycloisomerization of propargylic ureas
Peshkov, Vsevolod A.,Pereshivko, Olga P.,Sharma, Sweta,Meganathan, Thirumal,Parmar, Virinder S.,Ermolat'Ev, Denis S.,Van Der Eycken, Erik V.
experimental part, p. 5867 - 5872 (2011/09/14)
A one-pot protocol based on a Ag(I)-catalyzed cycloisomerization of propargylic ureas, derived from secondary propargylamines and isocyanates, was developed for the generation of the 2-imidazolone core.