1311403-81-2Relevant academic research and scientific papers
Migratory decarboxylative coupling of coumarins: Synthetic and mechanistic aspects
Jana, Ranjan,Partridge, James J.,Tunge, Jon A.
scheme or table, p. 5157 - 5161 (2011/07/30)
On the move: Decarboxylative coupling of allyl 4-methyl-3-carboxycoumarins provides the products of γ-allylation of the methyl group rather than the typical regiospecific α-allylation. Mechanistic studies show that intramolecular proton transfer from the 4-methyl group to the 3-carboxylate allows allylation of the remote methyl group. The resulting 4-butenyl-3-carboxyl coumarin undergoes Pd0-catalyzed decarboxylation to provide the observed products (see scheme). Copyright
