1311464-34-2Relevant academic research and scientific papers
Unexpected formation of (Z)-3-(halomethylene)isoindolinones from gem-dihalovinylbenzonitriles: Efficient synthesis of enyne-containing isoindolinones
Wang, Chengming,Sun, Caiyun,Weng, Fei,Gao, Mingchun,Liu, Bingxin,Xu, Bin
, p. 2984 - 2989 (2011/06/21)
An efficient one-pot procedure for the regioselective synthesis of (Z)-3-(halomethylene)-isoindolin-1-ones was developed from easily accessible 2-(2,2-dihalovinyl)benzonitriles. From this key intermediate, a variety of isoindolinones containing an enyne moiety were synthesized in good to excellent yields via palladium-catalyzed Sonogashira reaction. The generated enyne-containing isoindolinones could be further manipulated by iodide induced cyclization reaction to afford a versatile synthetic intermediate 5H-pyrrolo[2,1-a]isoindolol-5-one in high yield and could be further elaborated.
