1311483-39-2

Basic information

• Product Name: C₁₈H₂₀FN₃O₃
• Synonyms: C₁₈H₂₀FN₃O₃
• CAS NO: 1311483-39-2
• Molecular Weight: 345.374
• Mol File: 1311483-39-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₈H₂₀FN₃O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₂₀FN₃O₃(1311483-39-2)
• EPA Substance Registry System: C₁₈H₂₀FN₃O₃(1311483-39-2)

Safety Data

• Hazardous Substances Data: 1311483-39-2(Hazardous Substances Data)

Upstream product

• 25016-11-9 1-methylpyrazole-4-carbaldehyde 
• 52721-69-4 [2-(2-fluorophenyl)ethyl]amine 
• 108-55-4 glutaric anhydride, 

Relevant articles and documents

Toward lead-oriented synthesis: One-pot version of castagnoli condensation with nonactivated alicyclic anhydrides

One-pot variation of Castagnoli condensation, that is, reaction of cyclic anhydrides, amines, and aldehydes, has been developed as a combinatorial approach to 1,2-disubstituted 5-oxopyrrolidine- and 6-oxopiperidine-3-carboxylic acids, as well as their benzo-analogues. Utility of the method to multigram preparation of building blocks and synthetic intermediates was also demonstrated. The final products are obtained in high yields and diastereoselectivity. The method fits well in the concept of lead-oriented synthesis; in particular, it can be used for the design of lead-like compound libraries, even if the strictest cut-offs are applied to the physicochemical properties of their members.