131179-10-7Relevant articles and documents
The synthesis of epiboxidine and related analogues as potential pharmacological agents
Kulu, Irem,Ocal, Nuket
scheme or table, p. 2054 - 2060 (2012/01/04)
Methyl epiboxidine-N-carboxylate (8) was synthesized from 7 under reductive Heck conditions (Scheme 2). The C-C coupling of the new epiboxidine analog 9 with aryl and heteroaryl halides gave by hydroarylation C-aryl, N-(3-methylisoxazol-5-yl)-substituted
2-(Het)aryl-substituted 7-azabicyclo[2.2.1]heptane systems
Otten, Albert,Namyslo, Jan Christoph,Stoermer, Martin,Kaufmann, Dieter E.
, p. 1997 - 2001 (2007/10/03)
Epibatidine (1) is a recently discovered trace alkaloid found in the skin of a Latin-Amencan poisonous frog. Its remarkably high analgetic activity is accompanied by high toxicity. Therefore, in order to tune its biological activity, a convergent and effi
A Total Synthesis of (+/-)-Epibatidine
Clayton, Simon C.,Regan, Andrew C.
, p. 7493 - 7496 (2007/10/02)
A total synthesis of the potent non-opiate analgesic alcaloid epibatidine is described, in which the key step is reductive palladium-catalysed Heck-type coupling.The synthesis is concise (two steps from known compounds), highly convergent, and completely sttereoselective for the desired exo-isomer. - Key Words: Epibatidine, Analgesic, Alkaloid, Palladium-catalysed Coupling