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Usage

Thiazole derivative

A chemical compound containing a thiazole ring This indicates that the core structure of the compound is a thiazole ring, which is a five-membered heterocyclic ring with one sulfur and one nitrogen atom.

Nitro group

A functional group consisting of an oxygen and a nitrogen atom (-NO2) The presence of a nitro group in the compound suggests that it may have certain chemical and biological properties, such as being an oxidizing agent or having potential pharmacological activity.

Trifluoromethyl group

A functional group consisting of a carbon atom bonded to three fluorine atoms (-CF3) The presence of a trifluoromethyl group can influence the compound's reactivity, stability, and lipophilicity, which may affect its biological activity and pharmacokinetic properties.

Phenyl ring

A six-membered carbon ring with alternating single and double bonds The phenyl ring is a common structural motif in organic chemistry and can be found in many pharmaceuticals and agrochemicals.

Potential applications in pharmaceuticals and agrochemicals

The compound may have uses in the development of new drugs and pesticides This suggests that 2-((2-nitro-4-(trifluoromethyl)phenyl)thio)benzo[d]thiazole could be a valuable building block or active ingredient in the development of new products in these industries.

Upstream product

• 367-86-2 1-fluoro-2-nitro-4-trifluoromethyl-benzene 
• 149-30-4 2-Mercaptobenzothiazole 
• 121-17-5 2-chloro-3-nitro-5-trifluoromethylbenzene 

Relevant academic research and scientific papers

The [Cu]-catalyzed SNAR reactions: Direct amination of electron deficient aryl halides with sodium azide and the synthesis of arylthioethers under Cu(II) - Ascorbate redox system

A one pot [Cu]-promoted SNAr reaction of electron-deficient halobenzenes with sodium azide and the reduction of the intermediate aryl azides under the same Cu(II)-ascorbate redox conditions leading to anilines has been documented. Control experiments revealed that both ascorbate and proline play important role in the reaction path way. Further, the use of this catalytic Cu(II)-ascorbate redox system has been explored for the synthesis of arylthioethers.

STUDIES ON FLUORINE CONTAINING HETEROCYCLIC COMPOUNDS: 4. REACTIONS OF 3-NITRO-4-CHLOROBENZOTRIFLUORIDE AND 3,5-DINITRO-4-CHLOROBENZOTRIFLUORIDE WITH FIVE MEMBERED HETEROCYCLES

The reactions of 3-nitro-4-chlorobenzotrifluoride (1a) and 3,5-dinitro-4-chlorobenzotrifluoride (1b) with heterocycles (2-5) are described.Six S-linked and N-substituted heterocycles (6, 9-11, 13), such as 2-(2-nitro-4-trifluoromethylphenylthio)benzothiazole (9a), were prepared from the reactions of 1a with benzotriazole (2), 2-mercaptobenzothiazole (5a) and 2-mercaptobenzoxazole (5b) and from the reactions of 1b with 2, 1,2,4-triazole (3) and 5a in DMF respectively. 1a reacted with 2-mercaptothiazoline (4) to give the desired product 7 and bis(2-nitro-4-trifluoromethylphenyl) thioether (8). 3-(2-Benzoxazolyl)-2-benzoxazolinethione (15) was obtained from the reaction of 1b with 5b.The spectral data and elemental analyses were fully in accord with the proposed structures, and the possible mechanisms for these compounds and other by-products were discussed.