1312016-32-2Relevant academic research and scientific papers
Ethyl-2-(2-chloroethyl)acrylate: A new very versatile α- cyclopropylester cation synthon. Efficient synthesis of cyclopropane ester derivatives by Michael addition-induced cyclization reaction
Lachia, Mathilde,Iriart, Sébastien,Baalouch, Myriam,De Mesmaeker, Alain,Beaudegnies, Renaud
scheme or table, p. 3219 - 3222 (2011/06/28)
We report here the use of the readily accessible ethyl-2-(2-chloroethyl) acrylate as a new very versatile α-cyclopropylester cation synthon, which reacts efficiently and selectively with carbon-, nitrogen-, sulfur- or phosphorus-centered nucleophiles through Michael addition followed by intramolecular capture of the incipient ester enolate to afford funtionalized cyclopropane esters in high yields.
