131206-80-9Relevant academic research and scientific papers
Synthesis of Amino Acid Derivatives of Kojic Acid and Their Tyrosinase Inhibitory Activity
Kobayashi, Yoshikane,Kayahara, Hiroshi,Tadasa, Koji,Nakamura, Toshiko,Tanaka, Hiroshi
, p. 1745 - 1746 (2007/10/02)
Six N-carbobenzozy amino acid derivatives of kojic acid were synthesized to improve the tyrosinase inhibitory activity of kojic acid.All derivatives showed stronger activities than kojic acid.Among them, the L-phenylalanine derivative was the strongest inhibitor and its IC50 value was about 1/80 that for kojic acid.The inhibition mechanism of these derivatives is considered to be a noncompetitive one similar to that of kojic acid.
