1312092-18-4Relevant academic research and scientific papers
Allosteric P=O-based receptors for dicarboxylic acids
Jose, D. Amilan,Mon, Ignasi,Fernandez-Perez, Hector,Escudero-Adan, Eduardo C.,Benet-Buchholz,Vidal-Ferran, Anton
, p. 3632 - 3635 (2011)
The synthesis of new P=O-disubstituted receptors with appended crown ethers and their properties as receptors for dicarboxylic acids have been studied. High affinities have been observed (oxalic and malonic acids with 4-, 5-, 6-, or 8-crown ethers). Binding of a cationic effector within the crown ether unit resulted in a positive "allosteric" effect, which has been determined to be Krel = 7 in the best case (binding of malonic acid with Li + @ rac-3b).
