1312136-52-9

Upstream product

• 173152-85-7 (R)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propionic acid 
• 155887-05-1 (2R,4R)-4,5-(isopropylidenedioxy)-2-methylpentan-1-ol 
• 925-90-6 ethylmagnesium bromide 
• 1312136-48-3 C₂₂H₄₀O₃Si 
• 1312136-11-0 (R)-4-benzyl-3-((2R,4R,6R)-7-(benzyloxy)-2,6-dimethyl-4-(tert-butyldimethylsilyloxy)heptanoyl)oxazolidin-2-one 
• 1312136-45-0 C₃₁H₄₅NO₅Si 
• 1312136-08-5 (R)-4-benzyl-3-((4R,6R,E)-7-(benzyloxy)-6-methyl-4-(tert-butyldimethylsilyloxy)hept-2-enoyl)oxazolidin-2-one 
• 1312136-42-7 C₁₉H₃₂O₃Si 
• 1312136-03-0 (2R,4R)-5-(benzyloxy)-2-(tert-butyldimethylsilyloxy)-4-methylpentan-1-ol 
• 1312136-40-5 C₂₄H₄₂O₄Si 
• 1312136-38-1 C₁₈H₂₈O₄ 
• 1312136-00-7 (2R,4R)-5-(benzyloxy)-4-methylpentane-1,2-diol 
• 1312136-36-9 C₁₆H₂₄O₃ 
• 1312135-98-0 (R)-4-benzyl-3-((R)-3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-methylpropanoyl)oxazolidin-2-one 

Downstream Products

• 1312136-13-2 (4R,6R,8R)-9-(benzyloxy)-4,8-dimethyl-6-(tert-butyldimethylsilyloxy)nonan-3-one 
• 1312136-54-1 C₂₈H₅₄O₃Si₂ 
• 1312136-15-4 ((2R,4S,6R)-1-(benzyloxy)-2,6-dimethyl-7-methylenenonan-4-yloxy)(tert-butyl)dimethylsilane 

Relevant academic research and scientific papers

Synthesis of key fragments of amphidinolide Q - A cytotoxic 12-membered macrolide

β-Hydroxy aldehyde and alkyl ketone moieties were effectively synthesized as key intermediates of amphidinolide Q, a cytotoxic macrolide from the cultured dinoflagellate Amphidinium sp.. The asymmetric center of the former derivative was produced by Sharpless asymmetric epoxidation, followed by E-selective 1,4-addition to give the sp2 methyl group. Derivatization of the L-ascorbic acid derivative by Evans asymmetric alkylation and Peterson olefination provided the latter intermediate. The coupling reaction of the segments was examined.