13123-05-2 Usage
General Description
(6-3H)Thymidine is a radiolabeled form of thymidine, a nucleoside that plays a crucial role in DNA synthesis and repair. The addition of tritium at position 3 of the thymine base allows for the tracking and quantification of thymidine incorporation into nucleic acids through autoradiography or liquid scintillation counting. This radiolabeled compound has been widely used in cell biology and molecular biology research to study DNA synthesis, cell proliferation, and the effects of various compounds on DNA replication. Its use as a tracer in biochemical and pharmacological studies has provided valuable insights into the mechanisms of DNA repair, replication, and cell cycle regulation.
Check Digit Verification of cas no
The CAS Registry Mumber 13123-05-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,1,2 and 3 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 13123-05:
(7*1)+(6*3)+(5*1)+(4*2)+(3*3)+(2*0)+(1*5)=52
52 % 10 = 2
So 13123-05-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m0/s1/i3T
13123-05-2Relevant articles and documents
Synthesis of tritium-labelled 3′-azido-3′-deoxythymidine
Sidorov,Zverkov,Myasoedov,Jasko,Skoblov
, p. 669 - 676 (2003)
New approaches to the synthesis of 3′-azido-3′-deoxythymidine labelled with tritium in the heterocyclic base have been developed. With this aim, enzymatic transribosylation with [3H]thymine using the enzyme preparation from rat liver and a three-step chemical synthesis with use of the tritium labelled precursor were studies. The enzyme preparation did not catalyse the transfer of the 3′-azido-3′-deoxyribosyl fragment to the [3H]thymine residue. 5′-O-Benzoyl-2,3′-anhydrothymidine was taken as a precursor for the tritium labelling by the chemical methods. The resulting [3H]3′-azido-3′-deoxythymidine was obtained with a specific radioactivity of 18.3 Ci/mmol, the tritium is located in the C-6 position of the thymine residue. Copyright
