13123-05-2 Usage
Uses
Used in Cell Biology Research:
(6-3H)Thymidine is used as a tracer for studying DNA synthesis, cell proliferation, and the effects of various compounds on DNA replication. It helps researchers understand the mechanisms of DNA repair, replication, and cell cycle regulation.
Used in Molecular Biology Research:
(6-3H)Thymidine is used as a tool for investigating the dynamics of DNA synthesis and the impact of different factors on cellular processes. It provides valuable insights into the regulation of the cell cycle and the role of DNA repair mechanisms in maintaining genomic integrity.
Used in Biochemical and Pharmacological Studies:
(6-3H)Thymidine is used as a radiolabeled compound for tracking the incorporation of thymidine into nucleic acids, which aids in understanding the mechanisms of DNA repair and replication. This information is crucial for the development of new therapeutic strategies and the study of drug interactions with DNA synthesis and repair pathways.
Used in Diagnostic Applications:
(6-3H)Thymidine can be employed as a diagnostic tool to detect and monitor the progression of diseases that involve abnormal cell proliferation, such as cancer. By measuring the incorporation of (6-3H)Thymidine into DNA, clinicians can assess the effectiveness of treatments and make informed decisions about patient care.
Used in Radioimmunoassays:
(6-3H)Thymidine is used as a radiolabeled marker in radioimmunoassays to detect and quantify specific biomolecules, such as proteins or nucleic acids, in biological samples. This technique is widely used in research and clinical settings to study the presence and activity of various biological targets.
Check Digit Verification of cas no
The CAS Registry Mumber 13123-05-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,1,2 and 3 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 13123-05:
(7*1)+(6*3)+(5*1)+(4*2)+(3*3)+(2*0)+(1*5)=52
52 % 10 = 2
So 13123-05-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m0/s1/i3T
13123-05-2Relevant academic research and scientific papers
Sidorov,Zverkov,Myasoedov,Jasko,Skoblov
, p. 669 - 676 (2003)
New approaches to the synthesis of 3′-azido-3′-deoxythymidine labelled with tritium in the heterocyclic base have been developed. With this aim, enzymatic transribosylation with [3H]thymine using the enzyme preparation from rat liver and a three-step chemical synthesis with use of the tritium labelled precursor were studies. The enzyme preparation did not catalyse the transfer of the 3′-azido-3′-deoxyribosyl fragment to the [3H]thymine residue. 5′-O-Benzoyl-2,3′-anhydrothymidine was taken as a precursor for the tritium labelling by the chemical methods. The resulting [3H]3′-azido-3′-deoxythymidine was obtained with a specific radioactivity of 18.3 Ci/mmol, the tritium is located in the C-6 position of the thymine residue. Copyright
