131232-75-2 Usage
Uses
Used in Organic Synthesis:
(3S,4S)-3-amino-4-methyl-2-oxetanone p-toluenesulfonate salt is used as a chiral building block for the synthesis of biologically active molecules. Its unique molecular structure allows for the creation of various compounds with potential applications in different fields.
Used in Pharmaceutical Research:
(3S,4S)-3-amino-4-methyl-2-oxetanone p-toluenesulfonate salt is used as a key intermediate in the development of new pharmaceuticals. Its improved stability and solubility make it an ideal candidate for drug discovery and design, potentially leading to the creation of novel therapeutic agents.
Used in the Chemical Industry:
(3S,4S)-3-amino-4-methyl-2-oxetanone p-toluenesulfonate salt is used as a versatile reagent in the chemical industry. Its properties, such as stability and solubility, make it suitable for various chemical reactions and processes, contributing to the development of new materials and products.
Check Digit Verification of cas no
The CAS Registry Mumber 131232-75-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,1,2,3 and 2 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 131232-75:
(8*1)+(7*3)+(6*1)+(5*2)+(4*3)+(3*2)+(2*7)+(1*5)=82
82 % 10 = 2
So 131232-75-2 is a valid CAS Registry Number.
131232-75-2Relevant academic research and scientific papers
Synthesis and Acylation of Salts of L-Threonine β-Lactone: A Route to β-Lactone Antibiotics
Pu, Yunlong,Martin, Fionna M.,Vederas, John C.
, p. 1280 - 1283 (2007/10/02)
The synthesis and N-acylation of β-lactones derived from L-threonine and L-allo-threonine were investigated.Treatment of N--L-allo-threonine (7b) with 4-bromobenzenesulfonyl chloride in pyridine at -43 to 0 deg C gives the corresponding β-lactones 8a and 8b, respectively, in 45-56 percent yields.These can be deprotected with thiophenol or p-thiocresol in the presence of p-toluenesulfonic acid to produce optically pure salts of L-threonine β-lactone (9a) and its allo isomer 9b (65-92percent).Compound 9a is readily acylated by reagents such as acid chlorides (e.g., acetyl, benzoyl) and mixed anhydrides to afford N-acyl β-substituted β-lactones such as 10 (antibiotic SQ 26,517), 14, 15, and 16 in good yield (84-92percent).Reaction of β-lactones 8a, 8b, and 9a with HBr in acetic acid results in nucleophilic ring opening by bromide at the β-position to give pure isomers of 2-amino-3-bromobutanoic acid.
