13124-18-0

Usage

Uses

Used in Pharmaceutical Research:
(3,4-dichlorophenyl)hydrazine is used as a research compound for its potential in the development of new pharmaceuticals, particularly in the areas of cancer and tuberculosis treatment. Its unique chemical structure allows for exploration of its interactions with biological targets and disease mechanisms.
Used in Organic Synthesis:
As a key intermediate, (3,4-dichlorophenyl)hydrazine is used in the synthesis of various organic compounds, including agrochemicals and other pharmaceuticals. Its reactivity and functional groups make it a valuable building block in the creation of complex molecules.
Used in Cancer Treatment Research:
(3,4-dichlorophenyl)hydrazine is studied for its potential as an anticancer agent, with research focusing on its ability to target and affect cancer cells. (3,4-dichlorophenyl)hydrazine's properties are investigated for their impact on tumor growth and progression.
Used in Tuberculosis Treatment Research:
In addition to cancer, (3,4-dichlorophenyl)hydrazine is also explored for its potential role in treating tuberculosis. Its chemical properties are of interest in the development of new treatments for this infectious disease.

InChI:InChI=1/C6H6Cl2N2/c7-5-2-1-4(10-9)3-6(5)8/h1-3,10H,9H2

Upstream product

• 30930-66-6 3,4-dichlorobenzenediazonium cation 
• 50379-99-2 3,4-dichlorobenzenediazonium chloride 
• 95-76-1 m,p-dichloroaniline 
• 19763-90-7 3,4-dichlorophenylhydrazine hydrochloride 

Downstream Products

• 134504-13-5 (3,4-Dichloro-phenyl)-(3,4,6,7,8,9-hexahydro-2H-quinolizin-1-yl)-diazene 
• 96423-49-3 N-(3,4-Dichloro-phenyl)-N'-(4,5-dihydro-thiazol-2-yl)-hydrazine; hydrobromide 
• 96423-60-8 N-(3,4-Dichloro-phenyl)-N'-(5,6-dihydro-4H-[1,3]thiazin-2-yl)-hydrazine; hydrochloride 
• 77606-82-7 2-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro[1]benzothiopyrano[4,3-c]pyrazol-3-one 
• 89521-91-5 1-(3,4-dichorophenyl)hydrazine-1-carbonitrile 
• 24096-02-4 C₉H₁₁Cl₂N₃S 
• 102997-24-0 (Z)-2-Cyano-3-[N'-(3,4-dichloro-phenyl)-hydrazino]-but-2-enethioic acid amide 
• 14577-13-0 1-<3,4-Dichlor-phenyl>-4-ethyl-semicarbazid 
• 24096-03-5 C₁₀H₁₁Cl₂N₃S 
• 13123-99-4 2-acetyl-1-(3,4-dichlorophenyl)hydrazine 
• 14578-81-5 N-Propionyl-N'-(3,4-dichlor-phenyl)-hydrazin 
• 25217-40-7 (3,4-dichlorophenyl)carbamic acid tert-butyl ester 
• 894420-88-3 1-(3,4-dichloro-phenyl)-5-p-tolyl-1H-pyrazole-3-carboxylic acid ethyl ester 
• 209336-55-0 1-(3,4-dichlorophenyl)-3-hydroxypyrazole 

Relevant academic research and scientific papers

Regioselective radical arylation of anilines with arylhydrazines

Substituted 2-aminobiphenyls have been prepared from arylhydrazines and anilines via radical arylation reactions under simple oxidative conditions. The strong directing effect of the free and unprotonated amino functionality leads to high regioselectivities, and anilines have been shown to be significantly better aryl radical acceptors than nitrobenzenes or phenyl ethers. The methodology is also applicable to phenols, which react best as phenolates under strongly basic conditions. Finally, radical arylation reactions of anilines and anilinium salts under various conditions have for the first time demonstrated that regioselectivity can also be controlled through the rearomatization step and that the addition of an aryl radical to a substituted benzene might even be reversible.

SIGMA RECEPTOR INHIBITORS

The invention relates to compounds of formula (I) having pharmacological activity towards the sigma receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which the sigma receptor is involved.

AN EFFICIENT METHOD FOR THE CONVERSION OF ARYLHYDRAZINES INTO 2-ARYL-4,4-DIALKYLSEMICARBAZIDES

Arylhydrazines are converted into 2-aryl-4,4-dialkylsemicarbazides by subsequent reaction with chloroformate, phosgene, dialkylamine, and alkaline hydrolysis.

Antiimplantation Agents: Part I - 1-Arylthiosemicarbazides

Several 1-arylthiosemicarbazides, 2-arylhydrazinothiazolines and 2-arylhydrazinodihydrothiazines have been examined for their antiimplantation activity in rats.Among the active compounds, 4-methyl-1-(3,5-bistrifluoromethylphenyl)thiosemicarbazide (3, C 2696-Go) and the corresponding 4,4-dimethyl (47), ethyl (4), n-butyl (5) and allyl (6) derivatives completely inhibit implantation at doses 10, 3, 20, 20 and 30 mg/kg respectively.The 3,4-dichlorophenyl analogue (32) is effective at a dose of 30 mg/kg. 2-(3,5-Bistrifluoromethylphenyl)hydrazinothiazoline (51) and the corresponding dihydrothiazine (63) show a weaker activity.The biological profile of C 2696-Go has been investigated in detail.It appears to prevent implantation by its antiuterotropic activity and ability to inhibit desiduoma formation.

Pyrazol-4-acetic acid compounds

Pyrazol-4-acetic acid compounds, such as substituted pyrazol-4-acetic acid, its esters, amides, nitriles and their pharamaceutically acceptable salts and method for the preparation of these compounds are disclosed. The novel compounds are useful analgesics, anti-inflammatory, and antipyretics.

(Nitrofuryl)pyrazoles, their synthesis and use, and compositions containing them

3-(5-Nitro-2-furyl)pyrazoles unsubstituted in the 5-position and 5-(5-nitro-2-furyl)pyrazoles unsubstituted in the 3-position are antimicrobials and disinfectants. The compounds are structurally represented by one of the formulae: STR1 wherein A is --CHO, --CN, --COOH, a protected or derived aldehyde group or a protected or derived carboxylic acid group; B is 5-nitro-2-furyl; R1 is --H, substituted or unsubstituted hydrocarbyl (saturated or unsaturated; acyclic, alicyclic or aromatic; or araliphatic); substituted or unsubstituted (cycloaliphatic or aromatic) heterocyclic or acyl (carboxylic or carbonic acid); R2 is --H; and n is a positive whole number of at most 2.