1312446-16-4Relevant academic research and scientific papers
Synthesis and SAR study of tricyclic sulfones as γ-secretase inhibitors: C-6 and C-8 positions
Su, Jing,Tang, Haiqun,McKittrick, Brian A.,Xu, Ruo,Clader, John W.,Greenlee, William J.,Hyde, Lynn,Zhang, Lili
, p. 3447 - 3451 (2011/07/07)
SAR exploration at C-6 and C-8 positions of the tricyclic sulfone series was carried out. Several functional groups were found to be well tolerated at C-6 and C-8 positions. Selective combination of C-6 and C-8 modification resulted in new tricyclic sulfone analogs with efficacy in in vivo mouse Aβ40 lowering model.
