1312469-18-3Relevant academic research and scientific papers
The first total synthesis of (±)-zenkequinone B
Devulapally, Rammohan,Hon, Yung-Son
, p. 3183 - 3185 (2011)
The first total synthesis of tetrahydrobenzo[a]anthraquinone natural product (±)-zenkequinone B (1) is reported. The key step involves the TiCl4-promoted intramolecular cyclization of 4-aryl-2-hydroxybutanal diethyl acetal 4 to give compound 3.
Synthesis of Islatravir Enabled by a Catalytic, Enantioselective Alkynylation of a Ketone
Andreani, Teresa,Brunskill, Andrew,Fryszkowska, Anna,Huffman, Mark A.,Lévesque, Fran?ois,Li, Hongming,Maloney, Kevin M.,Mclaughlin, Mark,Nawrat, Christopher C.,Patel, Niki R.,Tschaen, David M.,Whittaker, Aaron M.,Xu, Yingju,Yang, Hao
, (2020)
The synthesis of the potent anti-HIV investigational treatment islatravir is described. The key step in this synthesis is a highly enantioselective catalytic asymmetric alkynylation of a ketone. This reaction is a rare example of the asymmetric addition o
