131252-46-5

Upstream product

• 91-16-7 1,2-dimethoxybenzene 
• 21615-34-9 2-Methoxybenzoyl chloride 
• 579-75-9 2-Methoxybenzoic acid 

Downstream Products

• 114795-18-5 1-(3,4-dimethoxy-phenyl)-1-(2-methoxy-phenyl)-2-phenyl-ethene 
• 1239703-18-4 5,2′‐dibromo‐2,4′,5′‐trihydroxydiphenylmethanone 
• 1239703-12-8 5,2'‐dibromo‐2,4,'5'‐trimethoxybenzophenone 

Relevant academic research and scientific papers

Process development and synthesis of process-related impurities of an efficient scale-up preparation of 5,2′-dibromo-2,4′,5′-trihydroxy diphenylmethanone as a new acute pyelonephritis candidate drug

Based on a foregoing gram-scale laboratory process, an efficient scale-up preparation process of 5,2′-dibromo-2,4′,5′-trihydroxydiphenylmethanone (LM49-API), a new acute pyelonephritis candidate drug, was developed and validated aiming to reduce by-produc

Synthesis and biological activity of halophenols as potent antioxidant and cytoprotective agents

A series of new bromophenols and chlorophenols were prepared by a practical route. The in vitro antioxidative activity of the halophenols was evaluated by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging assay, and their cytoprotective activity was also tested on hydrogen peroxide (H2O2)-induced injury in human umbilical vein endothelial cells (HUVEC). All halophenols tested displayed moderate to good DPPH radical-scavenging activity, and two bromophenols, 2,3′-dibromo-4,5,6′-trihydroxydiphenylmethanone (16c) and 2,3-dibromo-4,5-dihydroxydiphenylmethanone (17c) exhibited high protective activity against H2O2-induced injury in HUVEC with EC50 values of 0.4 and 0.8 μM, respectively. The preliminary structure-activity relationships of these compounds were also investigated in order to determine the essential structures required for their bioactivities.

BeCl2 as a new highly selective reagent for dealkylation of aryl-methyl ethers

An efficient and simple method is introduced for the selective removal of methyl group from poly aryl-methyl ethers, in some important derivatives of benzophenones, xanthones, anthraquinones, aryl esters, benzamides and nitroanisoles with BeCl2.