1312602-72-4

Upstream product

• 1312602-69-9 C₂₅H₂₅NO₃ 
• 1312602-70-2 C₂₇H₂₇NO₃S₂ 
• 1312602-65-5 C₂₄H₃₃NO₃Si 

Downstream Products

• 1312602-64-4 (4R,5R)-5-((S)-hydroxy(phenyl)methyl)-1-methyl-4-phenyl-pyrrolidin-2-one 

Relevant academic research and scientific papers

Selective 3- and 6-OH modification of (-)-clausenamide

(-)-Clausenamide is a drug candidate under Phase I clinical trial for treatment of Alzheimer's disease (AD). In order to elucidate the substituent related structure-activity relationship, six one-substituent modified (-)-clausenamide analogues were designed, and four of them, namely 3-O-methyl, 6-O-methyl, 3-des-hydroxyl and 6-des-hydroxyl analogues were prepared by selective 3- and 6-OH modification of (-)-clausenamide.