Welcome to LookChem.com Sign In|Join Free

CAS

  • or

1312603-26-1

[3-(2-chloro-5-methylpyrimidin-4-yl)phenyl]methanol is a chemical compound with the molecular formula C13H11ClN2O. It is a white to off-white crystalline solid that is a derivative of pyrimidine, a heterocyclic organic compound. [3-(2-chloro-5-methylpyrimidin-4-yl)phenyl]methanol is characterized by the presence of a chloro and methyl group in the pyrimidine ring, which makes it potentially useful for various biological and chemical applications. It is important to handle [3-(2-chloro-5-methylpyrimidin-4-yl)phenyl]methanol with caution, as it may have potential hazards if not handled properly.

1312603-26-1 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 1312603-26-1 Structure

  • Basic information

    1. Product Name: [3-(2-chloro-5-methylpyrimidin-4-yl)phenyl]methanol
    2. Synonyms: [3-(2-chloro-5-methylpyrimidin-4-yl)phenyl]methanol
    3. CAS NO:1312603-26-1
    4. Molecular Formula:
    5. Molecular Weight: 0
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1312603-26-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: [3-(2-chloro-5-methylpyrimidin-4-yl)phenyl]methanol(CAS DataBase Reference)
    10. NIST Chemistry Reference: [3-(2-chloro-5-methylpyrimidin-4-yl)phenyl]methanol(1312603-26-1)
    11. EPA Substance Registry System: [3-(2-chloro-5-methylpyrimidin-4-yl)phenyl]methanol(1312603-26-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1312603-26-1(Hazardous Substances Data)

1312603-26-1 Usage

Uses

Used in Pharmaceutical Synthesis:
[3-(2-chloro-5-methylpyrimidin-4-yl)phenyl]methanol is used as an intermediate in the synthesis of pharmaceuticals for various medical applications. Its unique chemical structure allows it to be a valuable building block in the development of new drugs.
Used in Agrochemical Synthesis:
[3-(2-chloro-5-methylpyrimidin-4-yl)phenyl]methanol is also used as an intermediate in the synthesis of agrochemicals, which are chemicals used in the agricultural industry to enhance crop protection and productivity.
Used in Organic Chemistry:
[3-(2-chloro-5-methylpyrimidin-4-yl)phenyl]methanol is used as a reagent or building block in various organic chemical reactions, contributing to the synthesis of a wide range of organic compounds for different industries.
Used in Research and Development:
Due to its unique structure and potential applications, [3-(2-chloro-5-methylpyrimidin-4-yl)phenyl]methanol is utilized in research and development for exploring new chemical reactions, understanding its properties, and identifying novel uses in various fields.

Check Digit Verification of cas no

The CAS Registry Mumber 1312603-26-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,1,2,6,0 and 3 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1312603-26:
(9*1)+(8*3)+(7*1)+(6*2)+(5*6)+(4*0)+(3*3)+(2*2)+(1*6)=101
101 % 10 = 1
So 1312603-26-1 is a valid CAS Registry Number.

1312603-26-1Relevant articles and documents

Discovery of the macrocycle 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7, 26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27) ,16,21,23-decaene (SB1518), a potent Janus Kinase 2/Fms-like tyrosine kinase-3 (JAK2/FLT3) inhibitor for the treatment of myelofibrosis and lymphoma

William, Anthony D.,Lee, Angeline C.-H.,Blanchard, Stéphanie,Poulsen, Anders,Teo, Ee Ling,Nagaraj, Harish,Tan, Evelyn,Chen, Dizhong,Williams, Meredith,Sun, Eric T.,Goh, Kee Chuan,Ong, Wai Chung,Goh, Siok Kun,Hart, Stefan,Jayaraman, Ramesh,Pasha, Mohammed Khalid,Ethirajulu, Kantharaj,Wood, Jeanette M.,Dymock, Brian W.

, p. 4638 - 4658 (2011)

Discovery of the activating mutation V617F in Janus Kinase 2 (JAK2 V617F), a tyrosine kinase critically involved in receptor signaling, recently ignited interest in JAK2 inhibitor therapy as a treatment for myelofibrosis (MF). Herein, we describe the design and synthesis of a series of small molecule 4-aryl-2-aminopyrimidine macrocycles and their biological evaluation against the JAK family of kinase enzymes and FLT3. The most promising leads were assessed for their in vitro ADME properties culminating in the discovery of 21c, a potent JAK2 (IC50 = 23 and 19 nM for JAK2 WT and JAK2V617F, respectively) and FLT3 (IC50 = 22 nM) inhibitor with selectivity against JAK1 and JAK3 (IC50 = 1280 and 520 nM, respectively). Further profiling of 21c in preclinical species and mouse xenograft and allograft models is described. Compound 21c (SB1518) was selected as a development candidate and progressed into clinical trials where it is currently in phase 2 for MF and lymphoma.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 1312603-26-1