1312605-99-4

Basic information

• Product Name: (2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)methanol
• Synonyms: (2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)methanol
• CAS NO: 1312605-99-4
• Molecular Weight: 314.365
• Mol File: 1312605-99-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)methanol(1312605-99-4)
• EPA Substance Registry System: (2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)methanol(1312605-99-4)

Safety Data

• Hazardous Substances Data: 1312605-99-4(Hazardous Substances Data)

Usage

General Description

The chemical compound (2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)methanol, also known as A-419259, is a potential drug candidate for the treatment of various diseases, including cancer and viral infections. It is a member of the naphthyridine class of compounds, which have shown promising biological activities in preclinical studies. The methylsulfonyl group in the molecule is believed to contribute to its pharmacological properties, potentially enhancing its potency and target selectivity. Further research and development of this compound may reveal its therapeutic potential in various medical applications.

Upstream product

• 1312605-98-3 methyl 2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridine-3-carboxylate 
• 1312605-87-0 methyl 3-(2-(methylsulfonyl)phenyl)-3-oxopropanoate 
• 75473-07-3 3-(2-(Methylsulphonyl)phenyl)-3-oxopropanenitrile 
• 53882-80-7 3-(2-bromophenyl)-3-oxopropanenitrile 
• 150281-83-7 2-ethenyl-3-nitropyridine 
• 5470-18-8 2-Chloro-3-nitropyridine 
• 55234-58-7 3-aminopyridine-2-carboxaldehyde 

Downstream Products

• 1312605-59-6 4-amino-6-(((1R)-1-(2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethyl)amino)-5-pyrimidinecarbonitrile 
• 1312605-58-5 4-amino-6-(((1S)-1-(2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethyl)amino)-5-pyrimidinecarbonitrile 
• 1312606-01-1 methyl (2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)methanol 
• 1312606-00-0 2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridine-3-carbaldehyde 
• 1312606-02-2 2-(1-(2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethyl)isoindoline-1,3-dione 
• 1312606-03-3 1-(2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethanamine 
• 1312606-04-4 4-Amino-6-((1-(2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethyl)amino)-5-pyrimidinecarbonitrile 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS AND THEIR USES

Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.