131265-35-5 Usage
Uses
Used in Research and Development:
8-AZIDO-2'-DEOXYADENOSINE is used as a reagent for the synthesis of 8-Azido-3’-O-anthraniloyl-2’-dADP and 2’-dATP. These synthesized compounds serve as fluorescent and photoactivable probes for the nucleotide-binding site of kinases or cyclases. The application of these probes is essential in understanding the molecular mechanisms and interactions of these enzymes, which are involved in various cellular processes, including signal transduction, cell growth, and differentiation.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 8-AZIDO-2'-DEOXYADENOSINE and its derivatives can be utilized in the development of novel therapeutic agents targeting kinases and cyclases. These enzymes are often dysregulated in various diseases, including cancer, and are considered potential therapeutic targets. By modulating their activity, 8-AZIDO-2'-DEOXYADENOSINE-based drugs may offer new treatment options for patients suffering from these conditions.
Used in Diagnostic Applications:
8-AZIDO-2'-DEOXYADENOSINE and its synthesized probes can also be employed in diagnostic applications, particularly in the detection and monitoring of diseases associated with the dysregulation of kinases and cyclases. The fluorescent and photoactivable properties of these probes allow for the visualization and quantification of enzyme activity, providing valuable information for disease diagnosis and treatment evaluation.
Check Digit Verification of cas no
The CAS Registry Mumber 131265-35-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,1,2,6 and 5 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 131265-35:
(8*1)+(7*3)+(6*1)+(5*2)+(4*6)+(3*5)+(2*3)+(1*5)=95
95 % 10 = 5
So 131265-35-5 is a valid CAS Registry Number.
131265-35-5Relevant academic research and scientific papers
Laayoun, Ali,Decout, Jean-Luc,Lhomme, Jean
, p. 4989 - 4990 (1994)
The hydrolytic stability of 2'-deoxypurine nucleosides is decreased by introduction of electronwithdrawing substituents at the C-8 position in the series of compounds 2-8, 10-14.The sulfone group causes a 2.9 x 104 rate acceleration for glycosidic, bond cleavage in compound 14.
Stable congener of 2',3'-dideoxyadenosine
-
, (2008/06/13)
The preseent invention is concerned with congeners of 2',3'-dideoxyadenosine (ddA) with modifications at the 2- and 8- positions to increase stability of the compounds from the standpoint of resistance to deamination and hydrolytic cleavage of the glycosidic bond.
