1312674-76-2

Basic information

• Product Name: dimethyl [4-(4-nitrophenyl)-5-pivaloyl-2H-pyrazol-3-yl]phosphonate
• CAS NO: 1312674-76-2
• Molecular Weight: 381.325
• Mol File: 1312674-76-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: dimethyl [4-(4-nitrophenyl)-5-pivaloyl-2H-pyrazol-3-yl]phosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl [4-(4-nitrophenyl)-5-pivaloyl-2H-pyrazol-3-yl]phosphonate(1312674-76-2)
• EPA Substance Registry System: dimethyl [4-(4-nitrophenyl)-5-pivaloyl-2H-pyrazol-3-yl]phosphonate(1312674-76-2)

Safety Data

• Hazardous Substances Data: 1312674-76-2(Hazardous Substances Data)

Upstream product

• 1577-04-4 4,4-dimethyl-1-(4-nitrophenyl)pent-1-en-3-one 
• 90965-06-3 dimethyl 1-(1-diazo-2-oxopropyl)phosphonate 
• 75-97-8 3,3-dimethyl-butan-2-one 
• 555-16-8 4-nitrobenzaldehdye 

Relevant articles and documents

Regioselective synthesis of 3-carbo-5-phosphonylpyrazoles through a one-pot Claisen-Schmidt/1,3-dipolar cycloaddition/oxidation sequence

A one-pot reaction involving an aldehyde, a methyl ketone, and the Bestmann-Ohira reagent has been developed for the synthesis of variously substituted 3-carbo-5-phosphonylpyrazoles. Our synthetic methodology features a domino Claisen-Schmidt/1,3-dipolar cycloaddition/oxidation sequence, which leads to the target compounds in excellent yields. We further demonstrated that this unprecedented sequence could also be combined with a copper-catalyzed azide-alkyne cycloaddition in a one-pot, four-step cascade process generating five new bonds and two heterocyclic rings. Copyright